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Aop: 331

AOP Title

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Formation of DNA photoproducts leading to mortality

Short name:

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Formation of DNA photoproducts leading to mortality

Graphical Representation

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Click to download graphical representation template

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Authors

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You Songa, b, *, Li Xiea, b, c, YeonKyeong Leeb,d, Knut Erik Tollefsena, b, c

a Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, N-0349 OSLO, Norway

b Centre for Environmental Radioactivity (CERAD), Norwegian University of Life Sciences (NMBU), Post box 5003, N-1432 Ås, Norway

c Norwegian University of Life Sciences (NMBU), Faculty of Environmental Sciences and Natural Resource Management (MINA), Post box 5003, N-1432 Ås, Norway

d Norwegian University of Life Sciences (NMBU), Faculty of Biosciences, P.O. Box 5003, N-1432 Ås, Norway

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on April 30, 2020 12:34

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Revision dates for related pages

Page Revision Date/Time
Increase, Formation of DNA photoproducts April 30, 2020 12:27
Increase, DNA double-strand break April 30, 2020 12:28
Increase, Apoptosis April 15, 2017 16:17
Increase, Mortality October 23, 2020 08:52
Increase, Formation of DNA photoproducts leads to Increase, DNA DSB April 30, 2020 12:30
Increase, Apoptosis leads to Increase, Mortality June 12, 2018 04:30
Increase, DNA DSB leads to Increase, Apoptosis April 30, 2020 12:30
Ultraviolet B radiation April 15, 2017 16:04

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1765 Increase, Formation of DNA photoproducts Increase, Formation of DNA photoproducts
KE 1766 Increase, DNA double-strand break Increase, DNA DSB
KE 1365 Increase, Apoptosis Increase, Apoptosis
AO 350 Increase, Mortality Increase, Mortality

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, Formation of DNA photoproducts leads to Increase, DNA DSB adjacent Moderate Low
Increase, DNA DSB leads to Increase, Apoptosis adjacent Moderate Low
Increase, Apoptosis leads to Increase, Mortality non-adjacent Moderate Low

Network View

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Stressors

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Name Evidence Term
Ultraviolet B radiation High

Life Stage Applicability

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Life stage Evidence
All life stages

Taxonomic Applicability

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Term Scientific Term Evidence Link
Daphnia magna Daphnia magna NCBI
Daphnia middendorffiana Daphnia middendorffiana NCBI
Daphnia pulex Daphnia pulex NCBI
Daphnia pulicaria Daphnia pulicaria NCBI
Daphnia parvula Daphnia parvula NCBI

Sex Applicability

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Sex Evidence
Unspecific

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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