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Event: 1521
Key Event Title
Decrease, Growth
Short name
Biological Context
Level of Biological Organization |
---|
Individual |
Key Event Components
Process | Object | Action |
---|---|---|
growth | multicellular organism | decreased |
Key Event Overview
AOPs Including This Key Event
AOP Name | Role of event in AOP | Point of Contact | Author Status | OECD Status |
---|---|---|---|---|
Uncoupling of OXPHOS leading to growth inhibition 1 | AdverseOutcome | You Song (send email) | Open for citation & comment | WPHA/WNT Endorsed |
Uncoupling of OXPHOS leading to growth inhibition 2 | AdverseOutcome | You Song (send email) | Open for citation & comment | Under Development |
Uncoupling of OXPHOS leading to growth inhibition 3 | AdverseOutcome | You Song (send email) | Under development: Not open for comment. Do not cite | Under Development |
Uncoupling of OXPHOS leading to growth inhibition 4 | AdverseOutcome | You Song (send email) | Under development: Not open for comment. Do not cite | Under Development |
Uncoupling of OXPHOS leading to growth inhibition 5 | AdverseOutcome | You Song (send email) | Under development: Not open for comment. Do not cite | Under Development |
Uncoupling of OXPHOS leading to growth inhibition 6 | AdverseOutcome | You Song (send email) | Under development: Not open for comment. Do not cite | Under Development |
Mitochondrial ATP synthase antagonism leading to growth inhibition (1) | AdverseOutcome | You Song (send email) | Under development: Not open for comment. Do not cite | |
Mitochondrial ATP synthase antagonism leading to growth inhibition (2) | AdverseOutcome | You Song (send email) | Under development: Not open for comment. Do not cite | |
Mitochondrial complex III antagonism leading to growth inhibition (1) | AdverseOutcome | You Song (send email) | Under development: Not open for comment. Do not cite | |
Mitochondrial complex III antagonism leading to growth inhibition (2) | AdverseOutcome | You Song (send email) | Under development: Not open for comment. Do not cite | |
Reduction in photophosphorylation leading to growth inhibition in aquatic plants | AdverseOutcome | Knut Erik Tollefsen (send email) | Under development: Not open for comment. Do not cite |
Stressors
Taxonomic Applicability
Life Stages
Life stage | Evidence |
---|---|
Embryo | High |
Juvenile | High |
Sex Applicability
Term | Evidence |
---|---|
Unspecific | High |
Key Event Description
Decreased growth refers to a reduction in size and/or weight of a tissue, organ or individual organism. Growth is normally controlled by growth factors and mainly achieved through cell proliferation (Conlon 1999).
How It Is Measured or Detected
Growth can be indicated by measuring weight, length, total volume, and/or total area of a tissue, organ or individual organism.
Domain of Applicability
Taxonomic applicability domain
This key event is in general applicable to all eukaryotes.
Life stage applicability domain
This key event is applicable to early life stages such as embryo and juvenile.
Sex applicability domain
This key event is sex-unspecific.
Evidence for Perturbation by Stressor
Regulatory Significance of the Adverse Outcome
Growth is a regulatory relevant chronic toxicity endpoint for almost all organisms. Multiple OECD test guidelines have included growth either as a main endpoint of concern, or as an additional endpoint to be considered in the toxicity assessments. Relevant test guidelines include, but not only limited to:
-Test No. 208: Terrestrial Plant Test: Seedling Emergence and Seedling Growth Test
-Test No. 212: Fish, Short-term Toxicity Test on Embryo and Sac-Fry Stages
-Test No. 215: Fish, Juvenile Growth Test
-Test No. 241: The Larval Amphibian Growth and Development Assay (LAGDA)
-Test No. 201: Freshwater Alga and Cyanobacteria, Growth Inhibition Test
-Test No. 221: Lemna sp. Growth Inhibition Test
-Test No. 228: Determination of Developmental Toxicity to Dipteran Dung Flies (Scathophaga stercoraria L. (Scathophagidae), Musca autumnalis De Geer (Muscidae))
-Test No. 211: Daphnia magna Reproduction Test
References
Conlon I, Raff M. 1999. Size control in animal development. Cell 96:235-244. DOI: 10.1016/s0092-8674(00)80563-2.