API XML

Aop: 290

AOP Title

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DNA methyltransferase inhibition leading to reduced fecundity associated population decline

Short name:

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DNMT inhibition leading to reduced fecundity associated population decline

Graphical Representation

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Click to download graphical representation template

Authors

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You Song (yso@niva.no)

Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, NO-0349 Oslo, Norway

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on April 22, 2019 05:22

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Revision dates for related pages

Page Revision Date/Time
Increase, DNA methyltransferase inhibition April 22, 2019 05:09
Increase, DNA hypomethylation April 22, 2019 04:53
Increase, Gene expression April 22, 2019 04:55
Decrease, Fecundity June 12, 2018 04:39
Decrease, Population trajectory September 26, 2017 11:33
Increase, DNMT inhibition leads to Increase, DNA hypomethylation April 22, 2019 04:59
Increase, DNA hypomethylation leads to Increase, Gene expression April 22, 2019 04:59
Increase, Gene expression leads to Decrease, Fecundity April 22, 2019 05:00
Decrease, Fecundity leads to Decrease, Population trajectory April 22, 2019 05:00
5-Azacytidine April 22, 2019 05:01
Decitabine April 22, 2019 05:03
Sinefungin April 22, 2019 05:03
Psammaplin A April 22, 2019 05:04
Hydralazine hydrochloride April 22, 2019 05:04
Zebularine April 22, 2019 05:05
RG 108 April 22, 2019 05:05
Temozolomide April 22, 2019 05:06

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1619 Increase, DNA methyltransferase inhibition Increase, DNMT inhibition
KE 1620 Increase, DNA hypomethylation Increase, DNA hypomethylation
KE 1621 Increase, Gene expression Increase, Gene expression
AO 328 Decrease, Fecundity Decrease, Fecundity
AO 360 Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, DNMT inhibition leads to Increase, DNA hypomethylation adjacent High
Increase, DNA hypomethylation leads to Increase, Gene expression adjacent
Increase, Gene expression leads to Decrease, Fecundity adjacent
Decrease, Fecundity leads to Decrease, Population trajectory adjacent

Network View

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Stressors

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature
Juvenile

Taxonomic Applicability

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Term Scientific Term Evidence Link
Daphnia magna Daphnia magna NCBI

Sex Applicability

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Sex Evidence
Female

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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