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Aop: 264

AOP Title

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Sulfonylurea receptor binding leading to premature molting associated mortality

Short name:

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SUR binding leading to mortality

Graphical Representation

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Click to download graphical representation template

Authors

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You Songa

a Section for Environmental Toxicology, Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, NO-0349 Oslo, Norway

Contact: you.song@niva.no

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on June 12, 2018 05:14

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Revision dates for related pages

Page Revision Date/Time
Increase, Sulfonylurea receptor binding May 24, 2018 16:09
Increase, Mortality December 03, 2016 16:33
Increase, Premature molting May 24, 2018 15:58
Decrease, Cuticular chitin synthesis May 24, 2018 15:58
Increase, Opening of voltage-dependent calcium channel May 24, 2018 16:19
Increase, Cell membrane depolarization May 24, 2018 16:20
Increase, SUR binding leads to Increase, Cell membrane depolarization May 24, 2018 16:22
Increase, Opening of voltage-dependent calcium channel leads to Decrease, Cuticular chitin synthesis May 24, 2018 16:23
Increase, Cell membrane depolarization leads to Increase, Opening of voltage-dependent calcium channel May 24, 2018 16:23
Decrease, Cuticular chitin synthesis leads to Increase, Premature molting May 24, 2018 15:59
Increase, Premature molting leads to Increase, Mortality May 24, 2018 16:00
Teflubenzuron May 24, 2018 16:15
Diflubenzuron May 24, 2018 16:15
Glibenclamide May 24, 2018 16:26

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 1525 Increase, Sulfonylurea receptor binding Increase, SUR binding
2 KE 1524 Increase, Premature molting Increase, Premature molting
3 KE 1523 Decrease, Cuticular chitin synthesis Decrease, Cuticular chitin synthesis
4 KE 1526 Increase, Opening of voltage-dependent calcium channel Increase, Opening of voltage-dependent calcium channel
5 KE 1527 Increase, Cell membrane depolarization Increase, Cell membrane depolarization
6 AO 350 Increase, Mortality Increase, Mortality

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, SUR binding leads to Increase, Cell membrane depolarization adjacent High
Increase, Cell membrane depolarization leads to Increase, Opening of voltage-dependent calcium channel adjacent High
Decrease, Cuticular chitin synthesis leads to Increase, Premature molting adjacent High
Increase, Premature molting leads to Increase, Mortality adjacent High
Increase, Opening of voltage-dependent calcium channel leads to Decrease, Cuticular chitin synthesis non-adjacent

Network View

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Stressors

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Name Evidence Term
Teflubenzuron High
Diflubenzuron High
Glibenclamide High

Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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