API XML

Aop: 286

AOP Title

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Mitochondrila Complex III inhibition leading to ATP depletion associated mortality

Short name:

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Complex III inhibition leading to mortality

Graphical Representation

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Click to download graphical representation template

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Authors

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You Song

Norwegian Institute for Water Research (NIVA), Oslo, Norway

Email: you.song@niva.no

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on March 19, 2019 09:53

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Revision dates for related pages

Page Revision Date/Time
Mitochondrial Complex III inhibition March 07, 2019 05:06
Decrease, Mitochondrial ATP production September 16, 2017 10:14
Increase, Necrosis March 19, 2019 09:31
Increase, Mortality December 03, 2016 16:33
Decrease, Oxidative phosphorylation December 20, 2018 10:16
Mitochondrial Complex III inhibition leads to Decrease, OXPHOS March 19, 2019 09:33
Decrease, OXPHOS leads to Decrease, Mitochondrial ATP production October 10, 2017 08:00
Decrease, Mitochondrial ATP production leads to Increase, Necrosis March 19, 2019 09:34
Increase, Necrosis leads to Increase, Mortality March 19, 2019 09:35
Antimycin A December 19, 2018 09:50

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 1542 Mitochondrial Complex III inhibition Mitochondrial Complex III inhibition
2 KE 1477 Decrease, Oxidative phosphorylation Decrease, OXPHOS
3 KE 40 Decrease, Mitochondrial ATP production Decrease, Mitochondrial ATP production
4 KE 1607 Increase, Necrosis Increase, Necrosis
5 AO 350 Increase, Mortality Increase, Mortality

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Mitochondrial Complex III inhibition leads to Decrease, OXPHOS adjacent High Not Specified
Decrease, OXPHOS leads to Decrease, Mitochondrial ATP production adjacent High Not Specified
Decrease, Mitochondrial ATP production leads to Increase, Necrosis adjacent Moderate Not Specified
Increase, Necrosis leads to Increase, Mortality adjacent Moderate Not Specified

Network View

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Stressors

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Name Evidence Term
Antimycin A High

Life Stage Applicability

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Life stage Evidence
Juvenile
Adult

Taxonomic Applicability

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Term Scientific Term Evidence Link
Lemna minor Lemna minor NCBI
Daphnia magna Daphnia magna NCBI
Danio rerio Danio rerio NCBI

Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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