API XML

Aop: 287

AOP Title

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Mitochondrila Complex III inhibition leading to oxidative stress associated mortality

Short name:

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Complex III inhibition leading to lethality

Graphical Representation

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Click to download graphical representation template

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Authors

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You Song

Norwegian Institute for Water Research (NIVA)

Email: you.song@niva.no

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on March 19, 2019 09:53

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Revision dates for related pages

Page Revision Date/Time
Mitochondrial Complex III inhibition March 07, 2019 05:06
Increase, Reactive oxygen species March 19, 2019 09:41
Increase, Oxidative DNA damage March 19, 2019 09:40
Increase, Apoptosis April 15, 2017 16:17
Increase, Mortality December 03, 2016 16:33
Mitochondrial Complex III inhibition leads to Increase, ROS March 19, 2019 09:42
Increase, ROS leads to Increase,Oxidative DNA damage March 19, 2019 09:42
Increase,Oxidative DNA damage leads to Increase, Apoptosis March 19, 2019 09:43
Increase, Apoptosis leads to Increase, Mortality June 12, 2018 04:30
Antimycin A December 19, 2018 09:50

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1542 Mitochondrial Complex III inhibition Mitochondrial Complex III inhibition
KE 1364 Increase, Reactive oxygen species Increase, ROS
KE 1608 Increase, Oxidative DNA damage Increase,Oxidative DNA damage
KE 1365 Increase, Apoptosis Increase, Apoptosis
AO 350 Increase, Mortality Increase, Mortality

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Mitochondrial Complex III inhibition leads to Increase, ROS adjacent High Not Specified
Increase, ROS leads to Increase,Oxidative DNA damage adjacent High Not Specified
Increase,Oxidative DNA damage leads to Increase, Apoptosis adjacent High Not Specified
Increase, Apoptosis leads to Increase, Mortality adjacent Moderate Not Specified

Network View

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Stressors

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Name Evidence Term
Antimycin A High

Life Stage Applicability

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Life stage Evidence
All life stages

Taxonomic Applicability

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Term Scientific Term Evidence Link
Lemna minor Lemna minor NCBI
Daphnia magna Daphnia magna NCBI
Danio rerio Danio rerio NCBI

Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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