API XML

Aop: 263

AOP Title

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Chitin synthase inhibition leading to premature molting associated mortality

Short name:

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CHS inhibition leading to mortality

Graphical Representation

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Click to download graphical representation template

Authors

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You Songa

a Section for Environmental Toxicology, Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, NO-0349 Oslo, Norway

Contact: you.song@niva.no

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on June 12, 2018 05:14

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Revision dates for related pages

Page Revision Date/Time
Increase, Chitin synthase inhibition May 24, 2018 15:57
Decrease, Cuticular chitin synthesis May 24, 2018 15:58
Increase, Premature molting May 24, 2018 15:58
Increase, Mortality December 03, 2016 16:33
Increase, CHS inhibition leads to Decrease, Cuticular chitin synthesis May 24, 2018 15:59
Decrease, Cuticular chitin synthesis leads to Increase, Premature molting May 24, 2018 15:59
Increase, Premature molting leads to Increase, Mortality May 24, 2018 16:00
Nikkomycins May 24, 2018 15:54
Polyoxin B May 24, 2018 15:54

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1522 Increase, Chitin synthase inhibition Increase, CHS inhibition
KE 1523 Decrease, Cuticular chitin synthesis Decrease, Cuticular chitin synthesis
KE 1524 Increase, Premature molting Increase, Premature molting
AO 350 Increase, Mortality Increase, Mortality

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, CHS inhibition leads to Decrease, Cuticular chitin synthesis adjacent High
Decrease, Cuticular chitin synthesis leads to Increase, Premature molting adjacent Moderate
Increase, Premature molting leads to Increase, Mortality adjacent High

Network View

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Stressors

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Name Evidence Term
Nikkomycins High
Polyoxin B High

Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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