API XML

Aop: 263

AOP Title

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ATP synthase inhibition leading to reduced fecundity (#1)

Short name:

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ATP synthase inhibition leading to reduced fecundity (#1)

Graphical Representation

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Click to download graphical representation template

Authors

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You Songa

a Section for Environmental Toxicology, Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, NO-0349 Oslo, Norway

Contact: you.song@niva.no

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development


This AOP was last modified on May 08, 2020 07:45

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Revision dates for related pages

Page Revision Date/Time
Increase, ATP synthase inhibition May 08, 2020 07:37
Decrease, Oxidative phosphorylation December 20, 2018 10:16
Decrease, ATP production April 30, 2020 12:42
Increase, Oocyte apoptosis April 30, 2020 16:41
Decrease, Oogenesis April 30, 2020 16:41
Decrease, Fecundity June 12, 2018 04:39
Increase, ATP synthase inhibition leads to Decrease, OXPHOS May 08, 2020 07:44
Decrease, OXPHOS leads to Decrease, ATP production April 30, 2020 12:44
Decrease, ATP production leads to Increase, Oocyte apoptosis May 08, 2020 07:44
Increase, Oocyte apoptosis leads to Decrease, Oogenesis April 30, 2020 16:44
Decrease, Oogenesis leads to Decrease, Fecundity June 12, 2018 04:41

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1785 Increase, ATP synthase inhibition Increase, ATP synthase inhibition
KE 1477 Decrease, Oxidative phosphorylation Decrease, OXPHOS
KE 1771 Decrease, ATP production Decrease, ATP production
KE 1775 Increase, Oocyte apoptosis Increase, Oocyte apoptosis
KE 1366 Decrease, Oogenesis Decrease, Oogenesis
AO 328 Decrease, Fecundity Decrease, Fecundity

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, ATP synthase inhibition leads to Decrease, OXPHOS adjacent
Decrease, OXPHOS leads to Decrease, ATP production adjacent
Decrease, ATP production leads to Increase, Oocyte apoptosis adjacent
Increase, Oocyte apoptosis leads to Decrease, Oogenesis adjacent
Decrease, Oogenesis leads to Decrease, Fecundity adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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