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Aop: 263
AOP Title
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ATP synthase inhibition leading to reduced fecundity (#1)
Short name:
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ATP synthase inhibition leading to reduced fecundity (#1)
Graphical Representation
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Click to download graphical representation template
Authors
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You Songa
a Section for Environmental Toxicology, Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, NO-0349 Oslo, Norway
Contact: you.song@niva.no
Point of Contact
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You Song
(email point of contact)
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Status
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| Author status |
OECD status |
OECD project |
SAAOP status |
| Under development: Not open for comment. Do not cite |
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Under Development |
This AOP was last modified on May 08, 2020 07:45
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Revision dates for related pages
| Page |
Revision Date/Time |
| Increase, ATP synthase inhibition |
May 08, 2020 07:37 |
| Decrease, Oxidative phosphorylation |
December 20, 2018 10:16 |
| Decrease, ATP production |
April 30, 2020 12:42 |
| Increase, Oocyte apoptosis |
April 30, 2020 16:41 |
| Decrease, Oogenesis |
April 30, 2020 16:41 |
| Decrease, Fecundity |
June 12, 2018 04:39 |
| Increase, ATP synthase inhibition leads to Decrease, OXPHOS |
May 08, 2020 07:44 |
| Decrease, OXPHOS leads to Decrease, ATP production |
April 30, 2020 12:44 |
| Decrease, ATP production leads to Increase, Oocyte apoptosis |
May 08, 2020 07:44 |
| Increase, Oocyte apoptosis leads to Decrease, Oogenesis |
April 30, 2020 16:44 |
| Decrease, Oogenesis leads to Decrease, Fecundity |
June 12, 2018 04:41 |
Abstract
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Background (optional)
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Summary of the AOP
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Events: Molecular Initiating Events (MIE)
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Key Events (KE)
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Adverse Outcomes (AO)
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| Sequence |
Type |
Event ID |
Title |
Short name |
Relationships Between Two Key Events
(Including MIEs and AOs)
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| Title |
Adjacency |
Evidence |
Quantitative Understanding |
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Increase, ATP synthase inhibition leads to Decrease, OXPHOS
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adjacent
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Decrease, OXPHOS leads to Decrease, ATP production
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adjacent
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Decrease, ATP production leads to Increase, Oocyte apoptosis
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adjacent
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Increase, Oocyte apoptosis leads to Decrease, Oogenesis
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adjacent
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Decrease, Oogenesis leads to Decrease, Fecundity
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adjacent
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Network View
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Stressors
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Life Stage Applicability
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Taxonomic Applicability
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Sex Applicability
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Overall Assessment of the AOP
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Domain of Applicability
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Essentiality of the Key Events
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Evidence Assessment
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Quantitative Understanding
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Considerations for Potential Applications of the AOP (optional)
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References
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