API XML

Aop: 268

AOP Title

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Uncoupling of oxidative phosphorylation leading to reproduction decline

Short name:

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Uncoupling of OXPHOS leading to reproduction decline

Graphical Representation

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Click to download graphical representation template

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Authors

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You Songa

a Section for Environmental Toxicology, Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, NO-0349 Oslo, Norway

Contact: you.song@niva.no

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on June 12, 2018 05:13

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Revision dates for related pages

Page Revision Date/Time
Increase, Uncoupling of oxidative phosphorylation June 29, 2017 08:05
Decrease, Mitochondrial ATP production September 16, 2017 10:14
Decrease, Oogenesis April 15, 2017 16:20
Decrease, Fecundity June 12, 2018 04:39
Decrease, Ovulation September 16, 2017 10:15
Increase, Uncoupling of OXPHOS leads to Decrease, Mitochondrial ATP production June 29, 2017 08:11
Decrease, Mitochondrial ATP production leads to Decrease, Oogenesis June 29, 2017 08:11
Decrease, Oogenesis leads to Decrease, Ovulation April 15, 2017 16:24
Decrease, Ovulation leads to Decrease, Fecundity June 12, 2018 04:44

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1446 Increase, Uncoupling of oxidative phosphorylation Increase, Uncoupling of OXPHOS
KE 40 Decrease, Mitochondrial ATP production Decrease, Mitochondrial ATP production
KE 1366 Decrease, Oogenesis Decrease, Oogenesis
KE 488 Decrease, Ovulation Decrease, Ovulation
AO 328 Decrease, Fecundity Decrease, Fecundity

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, Uncoupling of OXPHOS leads to Decrease, Mitochondrial ATP production adjacent High
Decrease, Mitochondrial ATP production leads to Decrease, Oogenesis adjacent Moderate
Decrease, Oogenesis leads to Decrease, Ovulation adjacent High
Decrease, Ovulation leads to Decrease, Fecundity adjacent High

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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