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Aop: 245

AOP Title

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Uncoupling of photophosphorylation leading to reduced ATP production associated growth inhibition

Short name:

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Uncoupling of photophosphorylation leading to growth inhibition

Graphical Representation

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Click to download graphical representation template

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Authors

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Li Xie, You Song and Knut Erik Tollefsen

Norwegian Institute for Water Research (NIVA)

Gaustadalléen 21, NO-0349 Oslo, Norway

 

Contact: ket@niva.no

Point of Contact

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Knut Erik Tollefsen   (email point of contact)

Contributors

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  • You Song
  • Knut Erik Tollefsen

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on October 10, 2017 08:44

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Revision dates for related pages

Page Revision Date/Time
Increase, Uncoupling of photophosphorylation October 10, 2017 07:48
Decrease, Chloroplast ATP production October 10, 2017 07:49
Decrease, Chlorophyll synthesis October 10, 2017 07:50
Decrease, Light harvest capacity October 10, 2017 07:50
Decrease, Photosynthesis October 10, 2017 07:51
Decrease, Glycolysis October 10, 2017 07:52
Decrease, Oxidative phosphorylation October 10, 2017 07:52
Decrease, Mitochondrial ATP production September 16, 2017 10:14
Decrease, Leaf cell mitosis October 10, 2017 07:53
Decrease, Leaf development October 10, 2017 07:54
Increase, Growth inhibition October 10, 2017 07:57
Increase, Uncoupling of photophosphorylation leads to Decrease, Chloroplast ATP production October 10, 2017 07:58
Decrease, Chloroplast ATP production leads to Decrease, Chlorophyll synthesis October 10, 2017 07:59
Decrease, Chlorophyll synthesis leads to Decrease, Light harvest capacity October 10, 2017 07:59
Decrease, Light harvest capacity leads to Decrease, Photosynthesis October 10, 2017 07:59
Decrease, Photosynthesis leads to Decrease, Glycolysis October 10, 2017 08:00
Decrease, Glycolysis leads to Decrease, OXPHOS October 10, 2017 08:00
Decrease, OXPHOS leads to Decrease, Mitochondrial ATP production October 10, 2017 08:00
Decrease, Mitochondrial ATP production leads to Decrease, Leaf cell mitosis October 10, 2017 08:00
Decrease, Leaf cell mitosis leads to Decrease, Leaf development October 10, 2017 08:01
Decrease, Leaf development leads to Increase, Growth inhibition October 10, 2017 08:01
3,5-Dichlorophenol October 10, 2017 07:47

Abstract

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Uncouplers of photophosphorylation have been identified as portent growth inhibitors of primer producers (e.g. aquatic plants) in aquatic ecosystem. This AOP causally links the uncoupling of photophosphorylation by organic compounds (e.g. 3,5-dichlorophenol) as the molecular initiating event and growth inhibition as the adverse outcome using the duckweed Lemna minor as a model. 

 


Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 1471 Increase, Uncoupling of photophosphorylation Increase, Uncoupling of photophosphorylation
2 KE 1472 Decrease, Chloroplast ATP production Decrease, Chloroplast ATP production
3 KE 1473 Decrease, Chlorophyll synthesis Decrease, Chlorophyll synthesis
4 KE 1474 Decrease, Light harvest capacity Decrease, Light harvest capacity
5 KE 1475 Decrease, Photosynthesis Decrease, Photosynthesis
6 KE 1476 Decrease, Glycolysis Decrease, Glycolysis
7 KE 1477 Decrease, Oxidative phosphorylation Decrease, OXPHOS
8 KE 40 Decrease, Mitochondrial ATP production Decrease, Mitochondrial ATP production
9 KE 1478 Decrease, Leaf cell mitosis Decrease, Leaf cell mitosis
10 KE 1479 Decrease, Leaf development Decrease, Leaf development
11 AO 1480 Increase, Growth inhibition Increase, Growth inhibition

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, Uncoupling of photophosphorylation leads to Decrease, Chloroplast ATP production adjacent High
Decrease, Chloroplast ATP production leads to Decrease, Chlorophyll synthesis adjacent Low
Decrease, Chlorophyll synthesis leads to Decrease, Light harvest capacity adjacent High
Decrease, Light harvest capacity leads to Decrease, Photosynthesis adjacent High
Decrease, Photosynthesis leads to Decrease, Glycolysis adjacent Moderate
Decrease, Glycolysis leads to Decrease, OXPHOS adjacent High
Decrease, OXPHOS leads to Decrease, Mitochondrial ATP production adjacent High
Decrease, Mitochondrial ATP production leads to Decrease, Leaf cell mitosis adjacent Moderate
Decrease, Leaf cell mitosis leads to Decrease, Leaf development adjacent High
Decrease, Leaf development leads to Increase, Growth inhibition adjacent High

Network View

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Stressors

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Name Evidence Term
3,5-Dichlorophenol Moderate

Life Stage Applicability

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Life stage Evidence
Development High

Taxonomic Applicability

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Term Scientific Term Evidence Link
Lemna minor Lemna minor Moderate NCBI
Lemna gibba Lemna gibba Moderate NCBI

Sex Applicability

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Sex Evidence
Unspecific High

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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