API XML

Aop: 266

AOP Title

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D1 protein blockage leading to apoptosis associated growth inhibition

Short name:

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D1 protein blockage leading growth inhibition

Graphical Representation

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Click to download graphical representation template

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Authors

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You Song1, Li Xie1, Knut Erik Tollefsen1

1 Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, NO-0349 Oslo, Norway

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song
  • Knut Erik Tollefsen

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on May 24, 2018 15:41

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Revision dates for related pages

Page Revision Date/Time
Increase, D1 protein blockage May 24, 2018 15:17
Decrease, Photosystem II activity May 24, 2018 15:17
Increase, Excessive reactive oxygen species generation June 29, 2017 07:51
Increase, DNA damage September 16, 2017 10:17
Increase, Apoptosis April 15, 2017 16:17
Decrease, Growth May 24, 2018 15:24
D1 protein blockage leads to PSII activity May 24, 2018 15:25
PSII activity leads to Increase, Excessive ROS generation May 24, 2018 15:39
Increase, Excessive ROS generation leads to Increase, DNA Damage June 29, 2017 07:51
Increase, DNA Damage leads to Increase, Apoptosis April 15, 2017 16:23
Increase, Apoptosis leads to Growth May 24, 2018 15:40

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1516 Increase, D1 protein blockage D1 protein blockage
KE 1517 Decrease, Photosystem II activity PSII activity
KE 1364 Increase, Excessive reactive oxygen species generation Increase, Excessive ROS generation
KE 1194 Increase, DNA damage Increase, DNA Damage
KE 1365 Increase, Apoptosis Increase, Apoptosis
AO 1521 Decrease, Growth Growth

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
D1 protein blockage leads to PSII activity adjacent High
PSII activity leads to Increase, Excessive ROS generation adjacent Moderate
Increase, Excessive ROS generation leads to Increase, DNA Damage adjacent High
Increase, DNA Damage leads to Increase, Apoptosis adjacent High
Increase, Apoptosis leads to Growth adjacent Low

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Lemna minor Lemna minor High NCBI
Lemna gibba Lemna gibba NCBI

Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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