API

Aop: 186

AOP Title

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unknown MIE leading to renal failure and mortality

Short name:

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unknown MIE renal failure

Authors

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Kellie Fay

Point of Contact

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Kellie Fay

Contributors

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  • Kellie Fay

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Unknown, MIE December 03, 2016 16:37
Increased, Reactive oxygen species September 16, 2017 10:17
Increased, Oxidative Stress September 16, 2017 10:16
Occurrence, renal proximal tubular necrosis September 16, 2017 10:16
Increased, blood potassium concentration September 16, 2017 10:16
Occurrence, cardiac arrhythmia September 16, 2017 10:17
Increased, Mortality May 15, 2017 11:34
Unknown, MIE leads to Increased, Reactive oxygen species December 03, 2016 16:38
Increased, Reactive oxygen species leads to Increased, Oxidative Stress December 03, 2016 16:38
Increased, Oxidative Stress leads to Occurrence, renal proximal tubular necrosis December 03, 2016 16:38
Occurrence, renal proximal tubular necrosis leads to Increased, blood potassium concentration December 03, 2016 16:38
Increased, blood potassium concentration leads to Occurrence, cardiac arrhythmia December 03, 2016 16:38
Occurrence, cardiac arrhythmia leads to Increased, Mortality December 03, 2016 16:38
Diclofenac sodium November 29, 2016 18:42

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Name Evidence Term
Diclofenac sodium

Molecular Initiating Event

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Title Short name
Unknown, MIE Unknown, MIE

Key Events

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Title Short name
Increased, Reactive oxygen species Increased, Reactive oxygen species
Increased, Oxidative Stress Increased, Oxidative Stress
Occurrence, renal proximal tubular necrosis Occurrence, renal proximal tubular necrosis
Increased, blood potassium concentration Increased, blood potassium concentration
Occurrence, cardiac arrhythmia Occurrence, cardiac arrhythmia

Adverse Outcome

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Title Short name
Increased, Mortality Increased, Mortality

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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