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Aop: 186

AOP Title

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unknown MIE leading to renal failure and mortality

Short name:

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unknown MIE renal failure

Graphical Representation

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Click to download graphical representation template

Authors

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Kellie Fay

Point of Contact

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Kellie Fay   (email point of contact)

Contributors

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  • Kellie Fay

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Unknown, MIE December 03, 2016 16:37
Increased, Reactive oxygen species November 27, 2017 13:15
Increased, Oxidative Stress September 16, 2017 10:16
Occurrence, renal proximal tubular necrosis September 16, 2017 10:16
Increased, blood potassium concentration September 16, 2017 10:16
Occurrence, cardiac arrhythmia September 16, 2017 10:17
Increased, Mortality May 15, 2017 11:34
Unknown, MIE leads to Increased, Reactive oxygen species December 03, 2016 16:38
Increased, Reactive oxygen species leads to Increased, Oxidative Stress December 03, 2016 16:38
Increased, Oxidative Stress leads to Occurrence, renal proximal tubular necrosis December 03, 2016 16:38
Occurrence, renal proximal tubular necrosis leads to Increased, blood potassium concentration December 03, 2016 16:38
Increased, blood potassium concentration leads to Occurrence, cardiac arrhythmia December 03, 2016 16:38
Occurrence, cardiac arrhythmia leads to Increased, Mortality December 03, 2016 16:38
Diclofenac sodium November 29, 2016 18:42

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 1114 Unknown, MIE Unknown, MIE
2 KE 1115 Increased, Reactive oxygen species Increased, Reactive oxygen species
3 KE 1088 Increased, Oxidative Stress Increased, Oxidative Stress
4 KE 1097 Occurrence, renal proximal tubular necrosis Occurrence, renal proximal tubular necrosis
5 KE 1098 Increased, blood potassium concentration Increased, blood potassium concentration
6 KE 1106 Occurrence, cardiac arrhythmia Occurrence, cardiac arrhythmia
7 AO 351 Increased, Mortality Increased, Mortality

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Unknown, MIE leads to Increased, Reactive oxygen species adjacent
Increased, Reactive oxygen species leads to Increased, Oxidative Stress adjacent
Occurrence, renal proximal tubular necrosis leads to Increased, blood potassium concentration adjacent
Increased, blood potassium concentration leads to Occurrence, cardiac arrhythmia adjacent
Occurrence, cardiac arrhythmia leads to Increased, Mortality adjacent
Increased, Oxidative Stress leads to Occurrence, renal proximal tubular necrosis non-adjacent

Network View

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Stressors

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Name Evidence Term
Diclofenac sodium

Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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