API

Relationship: 1134

Title

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Occurrence, renal proximal tubular necrosis leads to Increased, blood potassium concentration

Upstream event

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Occurrence, renal proximal tubular necrosis

Downstream event

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Increased, blood potassium concentration

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Directness Weight of Evidence Quantitative Understanding
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality directly leads to Moderate
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality directly leads to Strong
unknown MIE leading to renal failure and mortality directly leads to

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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How Does This Key Event Relationship Work

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Weight of Evidence

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Biological Plausibility

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Empirical Support for Linkage

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Uncertainties or Inconsistencies

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Quantitative Understanding of the Linkage

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Evidence Supporting Taxonomic Applicability

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References

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