API

Aop: 138

AOP Title

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Organic anion transporter (OAT1) inhibition leading to renal failure and mortality

Short name:

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OAT1 inhibition

Authors

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Kellie Fay

Point of Contact

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Kellie Fay

Contributors

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  • Kellie Fay

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Inhibition, organic anion transporter 1 (OAT1) September 16, 2017 10:16
Increased, blood uric acid concentration September 16, 2017 10:16
Occurrence, renal proximal tubular necrosis September 16, 2017 10:16
Increased, blood potassium concentration September 16, 2017 10:16
Increased, Mortality May 15, 2017 11:34
Decline, Population December 03, 2016 16:33
Occurrence, tophi (urate) deposition December 03, 2016 16:37
Occurrence, cardiac arrhythmia September 16, 2017 10:17
Increased, Oxidative Stress September 16, 2017 10:16
Inhibition, organic anion transporter 1 (OAT1) leads to Increased, blood uric acid concentration December 03, 2016 16:38
Increased, blood uric acid concentration leads to Occurrence, tophi (urate) deposition December 03, 2016 16:38
Occurrence, tophi (urate) deposition leads to Occurrence, renal proximal tubular necrosis December 03, 2016 16:38
Occurrence, renal proximal tubular necrosis leads to Increased, blood potassium concentration December 03, 2016 16:38
Increased, blood potassium concentration leads to Occurrence, cardiac arrhythmia December 03, 2016 16:38
Occurrence, cardiac arrhythmia leads to Increased, Mortality December 03, 2016 16:38
Occurrence, renal proximal tubular necrosis leads to Increased, blood uric acid concentration December 03, 2016 16:38
Increased, blood uric acid concentration leads to Increased, Oxidative Stress December 03, 2016 16:38
Increased, Oxidative Stress leads to Occurrence, renal proximal tubular necrosis December 03, 2016 16:38

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Inhibition, organic anion transporter 1 (OAT1) Inhibition, organic anion transporter 1 (OAT1)

Key Events

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Title Short name
Increased, blood uric acid concentration Increased, blood uric acid concentration
Occurrence, renal proximal tubular necrosis Occurrence, renal proximal tubular necrosis
Increased, blood potassium concentration Increased, blood potassium concentration
Occurrence, tophi (urate) deposition Occurrence, tophi (urate) deposition
Occurrence, cardiac arrhythmia Occurrence, cardiac arrhythmia
Increased, Oxidative Stress Increased, Oxidative Stress

Adverse Outcome

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Title Short name
Increased, Mortality Increased, Mortality
Decline, Population Decline, Population

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Adult Strong

Taxonomic Applicability

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Term Scientific Term Evidence Link
Gyps coprotheres Gyps coprotheres Strong NCBI
Gyps fulvus Gyps fulvus NCBI
Gyps bengalensis Gyps bengalensis Strong NCBI
Gyps africanus Gyps africanus Strong NCBI
Gyps himalayensis Gyps himalayensis Strong NCBI
Gallus gallus Gallus gallus Strong NCBI
Aegypius monachus Aegypius monachus Moderate NCBI
Gyps indicus Gyps indicus Strong NCBI

Sex Applicability

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Sex Evidence
Male
Female

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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