API

Aop: 177

AOP Title

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Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality

Short name:

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Cox1 inhibition renal failure

Authors

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Kellie Fay

Point of Contact

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Kellie Fay

Contributors

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  • Kellie Fay

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Decreased, Prostaglandin F2alpha concentration, plasma September 16, 2017 10:17
Occurrence, renal ischemia December 03, 2016 16:37
Occurrence, renal proximal tubular necrosis September 16, 2017 10:16
Increased, blood potassium concentration September 16, 2017 10:16
Increased, Mortality May 15, 2017 11:34
Decline, Population December 03, 2016 16:33
Inhibition, Cyclooxygenase 1 activity December 03, 2016 16:37
Occurrence, cardiac arrhythmia September 16, 2017 10:17
Increased, Oxidative Stress September 16, 2017 10:16
Increased, blood uric acid concentration September 16, 2017 10:16
Occurrence, tophi (urate) deposition December 03, 2016 16:37
Decreased, Prostaglandin F2alpha concentration, plasma leads to Occurrence, renal ischemia December 03, 2016 16:38
Occurrence, renal proximal tubular necrosis leads to Increased, blood potassium concentration December 03, 2016 16:38
Inhibition, Cyclooxygenase 1 activity leads to Decreased, Prostaglandin F2alpha concentration, plasma December 03, 2016 16:38
Increased, blood potassium concentration leads to Occurrence, cardiac arrhythmia December 03, 2016 16:38
Occurrence, cardiac arrhythmia leads to Increased, Mortality December 03, 2016 16:38
Occurrence, renal ischemia leads to Increased, Oxidative Stress December 03, 2016 16:38
Increased, Oxidative Stress leads to Occurrence, renal proximal tubular necrosis December 03, 2016 16:38
Occurrence, renal proximal tubular necrosis leads to Increased, blood uric acid concentration December 03, 2016 16:38
Increased, blood uric acid concentration leads to Occurrence, tophi (urate) deposition December 03, 2016 16:38
Occurrence, tophi (urate) deposition leads to Occurrence, renal proximal tubular necrosis December 03, 2016 16:38
Increased, blood uric acid concentration leads to Increased, Oxidative Stress December 03, 2016 16:38
flunixin meglumine November 29, 2016 18:42
Ketoprofen November 29, 2016 18:42
Diclofenac sodium November 29, 2016 18:42
Clofibrate November 29, 2016 18:42
Indomethacin November 29, 2016 18:42
Ibuprofen November 29, 2016 18:42
Meloxicam November 29, 2016 18:42
Celecoxib November 29, 2016 18:42
nimesulide November 29, 2016 18:42
Phenylbutazone November 29, 2016 18:42
Carprofen November 29, 2016 18:42

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Inhibition, Cyclooxygenase 1 activity Inhibition, Cyclooxygenase 1 activity

Key Events

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Title Short name
Decreased, Prostaglandin F2alpha concentration, plasma Decreased, Prostaglandin F2alpha concentration, plasma
Occurrence, renal ischemia Occurrence, renal ischemia
Occurrence, renal proximal tubular necrosis Occurrence, renal proximal tubular necrosis
Increased, blood potassium concentration Increased, blood potassium concentration
Occurrence, cardiac arrhythmia Occurrence, cardiac arrhythmia
Increased, Oxidative Stress Increased, Oxidative Stress
Increased, blood uric acid concentration Increased, blood uric acid concentration
Occurrence, tophi (urate) deposition Occurrence, tophi (urate) deposition

Adverse Outcome

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Title Short name
Increased, Mortality Increased, Mortality
Decline, Population Decline, Population

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Adult Strong

Taxonomic Applicability

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Term Scientific Term Evidence Link
Gyps coprotheres Gyps coprotheres Strong NCBI
Gyps rueppelli Gyps rueppellii Moderate NCBI
Gyps fulvus Gyps fulvus Strong NCBI
Gyps himalayensis Gyps himalayensis Moderate NCBI
Gyps bengalensis Gyps bengalensis Strong NCBI
Gyps africanus Gyps africanus Strong NCBI
Gyps indicus Gyps indicus Strong NCBI
Gallus gallus Gallus gallus Strong NCBI
Aegypius monachus Aegypius monachus Moderate NCBI

Sex Applicability

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Sex Evidence
Male Strong
Female Strong

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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