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Aop: 177

AOP Title

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Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality

Short name:

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Cox1 inhibition renal failure

Graphical Representation

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Click to download graphical representation template

Authors

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Kellie Fay

Point of Contact

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Kellie Fay   (email point of contact)

Contributors

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  • Kellie Fay

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Decreased, Prostaglandin F2alpha concentration, plasma September 16, 2017 10:17
Occurrence, renal ischemia December 03, 2016 16:37
Occurrence, renal proximal tubular necrosis September 16, 2017 10:16
Increased, blood potassium concentration September 16, 2017 10:16
Increased, Mortality May 15, 2017 11:34
Decline, Population December 03, 2016 16:33
Inhibition, Cyclooxygenase 1 activity December 03, 2016 16:37
Occurrence, cardiac arrhythmia September 16, 2017 10:17
Increased, Oxidative Stress September 16, 2017 10:16
Increased, blood uric acid concentration September 16, 2017 10:16
Occurrence, tophi (urate) deposition December 03, 2016 16:37
Decreased, Prostaglandin F2alpha concentration, plasma leads to Occurrence, renal ischemia December 03, 2016 16:38
Occurrence, renal proximal tubular necrosis leads to Increased, blood potassium concentration December 03, 2016 16:38
Inhibition, Cyclooxygenase 1 activity leads to Decreased, Prostaglandin F2alpha concentration, plasma December 03, 2016 16:38
Increased, blood potassium concentration leads to Occurrence, cardiac arrhythmia December 03, 2016 16:38
Occurrence, cardiac arrhythmia leads to Increased, Mortality December 03, 2016 16:38
Occurrence, renal ischemia leads to Increased, Oxidative Stress December 03, 2016 16:38
Increased, Oxidative Stress leads to Occurrence, renal proximal tubular necrosis December 03, 2016 16:38
Occurrence, renal proximal tubular necrosis leads to Increased, blood uric acid concentration December 03, 2016 16:38
Increased, blood uric acid concentration leads to Occurrence, tophi (urate) deposition December 03, 2016 16:38
Occurrence, tophi (urate) deposition leads to Occurrence, renal proximal tubular necrosis December 03, 2016 16:38
Increased, blood uric acid concentration leads to Increased, Oxidative Stress December 03, 2016 16:38
flunixin meglumine November 29, 2016 18:42
Ketoprofen November 29, 2016 18:42
Diclofenac sodium November 29, 2016 18:42
Clofibrate November 29, 2016 18:42
Indomethacin November 29, 2016 18:42
Ibuprofen November 29, 2016 18:42
Meloxicam November 29, 2016 18:42
Celecoxib November 29, 2016 18:42
nimesulide November 29, 2016 18:42
Phenylbutazone November 29, 2016 18:42
Carprofen November 29, 2016 18:42

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 1103 Inhibition, Cyclooxygenase 1 activity Inhibition, Cyclooxygenase 1 activity
2 KE 1104 Decreased, Prostaglandin F2alpha concentration, plasma Decreased, Prostaglandin F2alpha concentration, plasma
3 KE 1105 Occurrence, renal ischemia Occurrence, renal ischemia
4 KE 1097 Occurrence, renal proximal tubular necrosis Occurrence, renal proximal tubular necrosis
5 KE 1098 Increased, blood potassium concentration Increased, blood potassium concentration
6 KE 1106 Occurrence, cardiac arrhythmia Occurrence, cardiac arrhythmia
7 KE 1088 Increased, Oxidative Stress Increased, Oxidative Stress
8 KE 1096 Increased, blood uric acid concentration Increased, blood uric acid concentration
9 KE 1102 Occurrence, tophi (urate) deposition Occurrence, tophi (urate) deposition
10 AO 351 Increased, Mortality Increased, Mortality
11 AO 361 Decline, Population Decline, Population

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Decreased, Prostaglandin F2alpha concentration, plasma leads to Occurrence, renal ischemia adjacent Not Specified
Occurrence, renal proximal tubular necrosis leads to Increased, blood potassium concentration adjacent High
Inhibition, Cyclooxygenase 1 activity leads to Decreased, Prostaglandin F2alpha concentration, plasma adjacent
Increased, blood potassium concentration leads to Occurrence, cardiac arrhythmia adjacent
Occurrence, cardiac arrhythmia leads to Increased, Mortality adjacent
Occurrence, renal ischemia leads to Increased, Oxidative Stress adjacent
Increased, Oxidative Stress leads to Occurrence, renal proximal tubular necrosis adjacent
Occurrence, renal proximal tubular necrosis leads to Increased, blood uric acid concentration adjacent High
Increased, blood uric acid concentration leads to Occurrence, tophi (urate) deposition adjacent High
Occurrence, tophi (urate) deposition leads to Occurrence, renal proximal tubular necrosis adjacent
Increased, blood uric acid concentration leads to Increased, Oxidative Stress adjacent

Network View

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Stressors

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Life Stage Applicability

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Life stage Evidence
Adult High

Taxonomic Applicability

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Term Scientific Term Evidence Link
Gyps coprotheres Gyps coprotheres High NCBI
Gyps rueppelli Gyps rueppellii Moderate NCBI
Gyps fulvus Gyps fulvus High NCBI
Gyps himalayensis Gyps himalayensis Moderate NCBI
Gyps bengalensis Gyps bengalensis High NCBI
Gyps africanus Gyps africanus High NCBI
Gyps indicus Gyps indicus High NCBI
Gallus gallus Gallus gallus High NCBI
Aegypius monachus Aegypius monachus Moderate NCBI

Sex Applicability

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Sex Evidence
Male High
Female High

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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