API

Stressor: 191

Title

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Clofibrate

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Clofibrate DTXSID3020336 Clofibrate 637-07-0 KNHUKKLJHYUCFP-UHFFFAOYSA-N KNHUKKLJHYUCFP-UHFFFAOYSA-N

AOP Evidence

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Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality

There is no evidence text for this AOP



PPARalpha-dependent liver cancer

There is no evidence text for this AOP




Event Evidence

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Decreased, cholesterol

Feeding grass carp either a high-fat or high-carbohydrate diet causes increases in total cholesterol, HDL, and LDL. Clofibrate reduces the high cholesterol levels caused by these diets to levels similar to controls (Guo et al. 2015)




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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