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Aop: 328

AOP Title

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Excessive reactive oxygen species production leading to mortality (#2)

Short name:

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Excessive ROS leading to mortality (#2)

Graphical Representation

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Click to download graphical representation template

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Authors

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You Songa, b, *, Li Xiea, b, c, YeonKyeong Leeb,d, Knut Erik Tollefsena, b, c

a Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, N-0349 OSLO, Norway

b Centre for Environmental Radioactivity (CERAD), Norwegian University of Life Sciences (NMBU), Post box 5003, N-1432 Ås, Norway

c Norwegian University of Life Sciences (NMBU), Faculty of Environmental Sciences and Natural Resource Management (MINA), Post box 5003, N-1432 Ås, Norway

d Norwegian University of Life Sciences (NMBU), Faculty of Biosciences, P.O. Box 5003, N-1432 Ås, Norway

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on April 30, 2020 12:45

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Revision dates for related pages

Page Revision Date/Time
Increase, Reactive oxygen species production September 16, 2017 10:14
Decrease, Mitochondrial membrane potential April 30, 2020 12:41
Decrease, Oxidative phosphorylation December 20, 2018 10:16
Decrease, ATP production April 30, 2020 12:42
Increase, Mortality December 03, 2016 16:33
Increase, ROS production leads to Decrease, MMP April 30, 2020 12:43
Decrease, ATP production leads to Increase, Mortality April 30, 2020 12:45
Decrease, MMP leads to Decrease, OXPHOS April 30, 2020 12:44
Decrease, OXPHOS leads to Decrease, ATP production April 30, 2020 12:44
Ultraviolet B radiation April 15, 2017 16:04

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 257 Increase, Reactive oxygen species production Increase, ROS production
KE 1770 Decrease, Mitochondrial membrane potential Decrease, MMP
KE 1477 Decrease, Oxidative phosphorylation Decrease, OXPHOS
KE 1771 Decrease, ATP production Decrease, ATP production
AO 350 Increase, Mortality Increase, Mortality

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, ROS production leads to Decrease, MMP adjacent Moderate Low
Decrease, MMP leads to Decrease, OXPHOS adjacent High Low
Decrease, OXPHOS leads to Decrease, ATP production adjacent High Low
Decrease, ATP production leads to Increase, Mortality non-adjacent Moderate Low

Network View

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Stressors

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Name Evidence Term
Ultraviolet B radiation High

Life Stage Applicability

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Life stage Evidence
All life stages

Taxonomic Applicability

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Term Scientific Term Evidence Link
Daphnia magna Daphnia magna NCBI

Sex Applicability

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Sex Evidence
Unspecific

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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