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Aop: 311

AOP Title

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Excessive reactive oxygen species production leading to population decline via mitochondrial dysfunction

Short name:

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ROS production leading to population decline via mitochondrial dysfunction

Graphical Representation

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Click to download graphical representation template

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Authors

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You Song

Norwegian Institute for Water Research (NIVA), Gaustadalléen 21, NO-0349 Oslo, Norway

Point of Contact

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You Song   (email point of contact)

Contributors

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  • You Song

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on November 25, 2020 11:14

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Revision dates for related pages

Page Revision Date/Time
Increase, Reactive oxygen species production September 16, 2017 10:14
Decrease, Mitochondrial membrane potential April 30, 2020 12:41
Decrease, Oxidative phosphorylation December 20, 2018 10:16
Decrease, Adenosine triphosphate pool November 29, 2020 16:12
Decrease, Oogenesis April 30, 2020 16:41
Decrease, Fecundity June 12, 2018 04:39
Decrease, Population trajectory September 26, 2017 11:33
Increase, ROS production leads to Decrease, MMP April 30, 2020 12:43
Decrease, MMP leads to Decrease, OXPHOS April 30, 2020 12:44
Decrease, OXPHOS leads to Decrease, ATP pool April 30, 2020 12:44
Decrease, ATP pool leads to Decrease, Oogenesis November 25, 2020 10:31
Decrease, Oogenesis leads to Decrease, Fecundity June 12, 2018 04:41
Decrease, Fecundity leads to Decrease, Population trajectory April 22, 2019 05:00
Gamma radiation April 15, 2017 16:04

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 257 Increase, Reactive oxygen species production Increase, ROS production
KE 1770 Decrease, Mitochondrial membrane potential Decrease, MMP
KE 1477 Decrease, Oxidative phosphorylation Decrease, OXPHOS
KE 1771 Decrease, Adenosine triphosphate pool Decrease, ATP pool
KE 1366 Decrease, Oogenesis Decrease, Oogenesis
AO 328 Decrease, Fecundity Decrease, Fecundity
AO 360 Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, ROS production leads to Decrease, MMP adjacent
Decrease, MMP leads to Decrease, OXPHOS adjacent
Decrease, OXPHOS leads to Decrease, ATP pool adjacent
Decrease, ATP pool leads to Decrease, Oogenesis adjacent
Decrease, Oogenesis leads to Decrease, Fecundity adjacent
Decrease, Fecundity leads to Decrease, Population trajectory adjacent

Network View

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Stressors

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Name Evidence Term
Gamma radiation High

Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature

Taxonomic Applicability

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Term Scientific Term Evidence Link
Daphnia magna Daphnia magna NCBI

Sex Applicability

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Sex Evidence
Female

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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