API XML

Aop: 319

AOP Title

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ACE2 inhibition leading to lung fibrosis

Short name:

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ACE2 inhibition, lung fibrosis

Graphical Representation

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Click to download graphical representation template

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Authors

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Point of Contact

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Young Jun Kim   (email point of contact)

Contributors

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  • Young Jun Kim

Status

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Author status OECD status OECD project SAAOP status
Open for comment. Do not cite

This AOP was last modified on March 17, 2020 06:18

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Revision dates for related pages

Page Revision Date/Time
Increase,collagen synthesis March 10, 2020 01:07
ACE2 inhibition March 10, 2020 00:54
Increase plasma Ang II March 10, 2020 01:01
Increases AngII March 17, 2020 06:15
Induction lung fibrosis March 10, 2020 01:11
ACE2 inhibition leads to Increases AngII March 17, 2020 06:17
Increases AngII leads to Increase plasma Ang II March 17, 2020 06:17
Increase plasma Ang II leads to Increase,collagen synthesis March 17, 2020 06:18
Increase,collagen synthesis leads to Induction lung fibrosis March 17, 2020 06:18
PM 2.5 March 02, 2020 05:42

Abstract

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Background (optional)

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Angiotensin-converting enzyme 2 (ACE2) is an exopeptidase that catalyzes the conversion of angiotensin I to the conversion of angiotensin II to angiotensin 1-7. This AOP describes the lung fibrosis can be caused by profibrotic cytokines such as angiotensin II(Ang II), which can further lead to pulmonary fibrosis by excessive collagen deposition. Besides, AngII has been shown to stimulate and interact with TGF beta as the most potent profibrotic factor.


Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1740 ACE2 inhibition ACE2 inhibition
KE 1752 Increases AngII Increases AngII
KE 1743 Increase plasma Ang II Increase plasma Ang II
KE 1745 Increase,collagen synthesis Increase,collagen synthesis
AO 1746 Induction lung fibrosis Induction lung fibrosis

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
ACE2 inhibition leads to Increases AngII adjacent High Moderate
Increases AngII leads to Increase plasma Ang II adjacent High Moderate
Increase plasma Ang II leads to Increase,collagen synthesis adjacent Moderate Low
Increase,collagen synthesis leads to Induction lung fibrosis adjacent Moderate Low

Network View

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Stressors

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Name Evidence Term
PM 2.5 High

Life Stage Applicability

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Life stage Evidence
Not Otherwise Specified Moderate

Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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