AOPs Including This Stressor
|Inhibition of Angiotensin-converting enzyme 2 leading to lung fibrosis||High|
Events Including This Stressor
Instillation of particulate matter 2.5 induced acute lung injury and attenuated the injury recovery in ACE2 knockout mice,Int. J. Biol. Sci. 2018, Vol. 14
Intratracheal instillation of PM 2.5 (collected at a major city of central China; 4 mg/kg body weight) in Balb/c mice once a day for 5 consecutive days induced phosphorylation of EGFR (Tyr1068) in lung tissues (Jin et al., 2016).
Intratracheal instillation of PM 2.5 (collected at Seoul, Korea), either as an aqueous extract or a dichloromethane extract at high concentrations (164 µg/50 µL), in Balb/c mice once a week for 4 weeks induced phosphorylation of EGFR (Tyr1068) in lung tissues (Jeong et al., 2017).
Treatment of human immortalized bronchial epithelial BEAS-2B cells with with 0, 20, 50, 100 and 150 μg/mL PM 2.5 (collected on the roof of Science and Technology Building on the campus of Xinxiang Medical University, China) for 6 h increased EGFR Y1068 phosphorylation in a concentration-dependent manner (Wang et al., 2020).