API

Event: 1276

Key Event Title

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Lung fibrosis

Short name

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Lung fibrosis

Biological Context

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Level of Biological Organization
Organ


Organ term

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Key Event Components

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Process Object Action

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
PPARγ inactivation leading to lung fibrosis AdverseOutcome

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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This consecutive KE resulting in the acquisition of the accumulation of excess fibrous connective tissue, the adverse outcome on pulmonary fibrosis. Scar formation, the accumulation of excess fibrous connective tissue (the process called fibrosis), leads to thickening of the walls, and causes reduced oxygen supply in the blood. As a consequence patients suffer from perpetual shortness of breath.


How It Is Measured or Detected

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Domain of Applicability

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Regulatory Significance of the Adverse Outcome

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References

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