This AOP focusses on the inhibition of any of the mitochondrial complexes (I,II,III,IV or V) which eventually leads to the initiation of liver injury. In short, inhibition (fully or partially) of mitochondrial complexes that form the OXPHOS will lead to perturbation of the OXPHOS itself. OXPHOS perturbation will manifest as lower or no production of ATP via the mitochondria. Besides OXPHOS perturbation, the inhibition of the complexes will also lead to accumulation of the unused electrons and therefore ROS formation. Both process combined will trigger mitochondrial injury. One the most important additions to the AOPwiki by us would be to improve the mitochondrial injury key event with more detail, more method descriptions and more evidence. Finally when a certain threshold is reached mitochondria cannot coop with the induced stress and will trigger the cell death pathways (apoptosis and necrosis depending on ATP availability). Evidently, the cell death will proceed to necrotic tissue and in the end to liver injury.