API

Event: 1548

Key Event Title

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Necrotic Tissue

Short name

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Necrotic Tissue

Biological Context

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Level of Biological Organization
Tissue


Organ term

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Key Event Components

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Process Object Action

Key Event Overview


AOPs Including This Key Event

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Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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Taxa = necrotic tissue in the liver

During the process of towards necrotic tissue, too many cells die. In practice it is difficult to distinguish separate forms of cell death (apoptosis, necrosis and necroptosis), especially in vivo.


How It Is Measured or Detected

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Histopathology: performed on tissue sections

· Hematoxylin (nuclei) and eosin staining: determine morphology

· TUNEL staining: cell death

https://medical-dictionary.thefreedictionary.com/Necrotic+tissue

https://livertox.nih.gov/Phenotypes_ahn.html

(Weng et al. 2015)

(Guicciardi et al. 2013)


Domain of Applicability

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Regulatory Significance of the Adverse Outcome

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References

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Guicciardi, M.E. et al., 2013. Apoptosis and Necrosis in the Liver. Comprehensive Physiology, 3(2), pp.977–1010. Available at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3867948&tool=pmcentrez&rendertype=abstract.

Weng, H. et al., 2015. Two sides of one coin: Massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure. Frontiers in Physiology, 6(MAY), pp.1–12.