API

Aop: 122

AOP Title

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Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation

Short name:

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Prolyl hydroxylase inhibition

Authors

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Dalma Martinovic-Weigelt

Point of Contact

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Dalma Martinovic-Weigelt

Contributors

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  • Dalma Martinovic-Weigelt

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Inhibition, Prolyl hydroxylases December 03, 2016 16:37
Increased, HIF-1 heterodimer December 03, 2016 16:37
Decreased, Aromatase (Cyp19a1) mRNA September 16, 2017 10:16
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells September 16, 2017 10:14
Reduction, Plasma 17beta-estradiol concentrations September 26, 2017 11:30
Reduction, Vitellogenin synthesis in liver September 16, 2017 10:16
Reduction, Plasma vitellogenin concentrations September 16, 2017 10:14
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development September 16, 2017 10:14
Reduction, Cumulative fecundity and spawning March 20, 2017 17:52
Decrease, Population trajectory September 26, 2017 11:33
Inhibition, Prolyl hydroxylases leads to Increased, HIF-1 heterodimer December 03, 2016 16:38
Increased, HIF-1 heterodimer leads to Decreased, Aromatase (Cyp19a1) mRNA December 03, 2016 16:38
Decreased, Aromatase (Cyp19a1) mRNA leads to Reduction, 17beta-estradiol synthesis by ovarian granulosa cells December 03, 2016 16:38
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells leads to Reduction, Plasma 17beta-estradiol concentrations March 20, 2017 12:05
Reduction, Plasma 17beta-estradiol concentrations leads to Reduction, Vitellogenin synthesis in liver March 20, 2017 12:28
Reduction, Vitellogenin synthesis in liver leads to Reduction, Plasma vitellogenin concentrations March 20, 2017 12:58
Reduction, Plasma vitellogenin concentrations leads to Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development March 20, 2017 13:21
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development leads to Reduction, Cumulative fecundity and spawning March 20, 2017 13:35
Reduction, Cumulative fecundity and spawning leads to Decrease, Population trajectory March 20, 2017 13:49

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Inhibition, Prolyl hydroxylases Inhibition, Prolyl hydroxylases

Key Events

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Title Short name
Increased, HIF-1 heterodimer Increased, HIF-1 heterodimer
Decreased, Aromatase (Cyp19a1) mRNA Decreased, Aromatase (Cyp19a1) mRNA
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Reduction, Plasma 17beta-estradiol concentrations Reduction, Plasma 17beta-estradiol concentrations
Reduction, Vitellogenin synthesis in liver Reduction, Vitellogenin synthesis in liver
Reduction, Plasma vitellogenin concentrations Reduction, Plasma vitellogenin concentrations
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development

Adverse Outcome

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Title Short name
Reduction, Cumulative fecundity and spawning Reduction, Cumulative fecundity and spawning
Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature

Taxonomic Applicability

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Term Scientific Term Evidence Link
Pimephales promelas Pimephales promelas NCBI

Sex Applicability

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Sex Evidence
Female

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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