To the extent possible under law, AOP-Wiki has waived all copyright and related or neighboring rights to KER:337
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development leads to Reduction, Cumulative fecundity and spawning
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding||Point of Contact||Author Status||OECD Status|
|Aromatase inhibition leading to reproductive dysfunction||adjacent||Moderate||Moderate||Dan Villeneuve (send email)||Open for citation & comment||TFHA/WNT Endorsed|
|Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)||adjacent||Moderate||Moderate||Dan Villeneuve (send email)||Open for citation & comment||TFHA/WNT Endorsed|
|Estrogen receptor antagonism leading to reproductive dysfunction||adjacent||Moderate||Moderate||Dan Villeneuve (send email)||Open for citation & comment||EAGMST Under Review|
|Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation||adjacent||Dalma Martinovic-Weigelt (send email)||Under Development: Contributions and Comments Welcome|
|Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription||adjacent||Dalma Martinovic-Weigelt (send email)||Under Development: Contributions and Comments Welcome|
|Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR||adjacent||Moderate||Moderate||Jon Doering (send email)||Under development: Not open for comment. Do not cite|
Life Stage Applicability
|Adult, reproductively mature||High|
Key Event Relationship Description
SEE BIOLOGICAL PLAUSIBILITY BELOW
Evidence Supporting this KER
Vitellogenesis is a critical stage of oocyte development and accumulated lipids and yolk proteins make up the majority of oocyte biomass (Tyler and Sumpter 1996). At least in mammals, maintenance of meiotic arrest is supported by signals transmitted through gap junctions between the granulosa cells and oocytes (Jamnongjit and Hammes 2005). Disruption of oocyte-granulosa contacts as a result of cell growth has been shown to coincide with oocyte maturation (Eppig 1994). However, it remains unclear whether the relationship between vitellogenin accumulation and oocyte growth and eventual maturation is causal or simply correlative.
Uncertainties and Inconsistencies
Based on the limited number of studies available that have examined both of these KEs, there are no known, unexplained, results that are inconsistent with this relationship.
Known modulating factors
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
On the basis of the taxonomic relevance of the two KEs linked via this KER, this KER is likely applicable to aquatic, oviparous, vertebrates which both produce vitellogenin and deposit eggs/sperm into an aquatic environment.
- Ankley GT, Jensen KM, Makynen EA, Kahl MD, Korte JJ, Hornung MW, Henry TR, Denny JS, Leino RL, Wilson VS, Cardon MC, Hartig PC, Gray LE. Effects of the androgenic growth promoter 17-beta-trenbolone on fecundity and reproductive endocrinology of the fathead minnow. Environ Toxicol Chem. 2003 Jun;22(6):1350-60.
- Eppig JJ. 1994. Further reflections on culture systems for the growth of oocytes in vitro. Human reproduction 9(6): 974-976.
- Jamnongjit M, Hammes SR. 2005. Oocyte maturation: the coming of age of a germ cell. Seminars in reproductive medicine 23(3): 234-241.
- Kang IJ, Yokota H, Oshima Y, Tsuruda Y, Shimasaki Y, Honjo T. The effects of methyltestosterone on the sexual development and reproduction of adult medaka (Oryzias latipes). Aquat Toxicol. 2008 Apr 8;87(1):37-46. doi: 10.1016/j.aquatox.2008.01.010.
- Li Z, Villeneuve DL, Jensen KM, Ankley GT, Watanabe KH. 2011b. A computational model for asynchronous oocyte growth dynamics in a batch-spawning fish. Can J Fish Aquat Sci 68: 1528-1538.
- Miller DH, Jensen KM, Villeneuve DL, Kahl MD, Makynen EA, Durhan EJ, et al. 2007. Linkage of biochemical responses to population-level effects: a case study with vitellogenin in the fathead minnow (Pimephales promelas). Environ Toxicol Chem 26(3): 521-527.
- Tyler C, Sumpter J. 1996. Oocyte growth and development in teleosts. Reviews in Fish Biology and Fisheries 6: 287-318.