API

Aop: 123

AOP Title

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Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription

Short name:

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Unknown MIE leading to reprodl

Authors

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Dalma Martinovic-Weigelt

Point of Contact

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Dalma Martinovic-Weigelt

Contributors

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  • Dalma Martinovic-Weigelt

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
modulation, Unknown December 03, 2016 16:37
Increased, HIF-1 heterodimer December 03, 2016 16:37
Increased, HIF-1 alpha transcription December 03, 2016 16:37
Decreased, Aromatase (Cyp19a1) mRNA September 16, 2017 10:16
Reduction, Plasma 17beta-estradiol concentrations September 26, 2017 11:30
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells September 16, 2017 10:14
Reduction, Vitellogenin synthesis in liver September 16, 2017 10:16
Reduction, Plasma vitellogenin concentrations September 16, 2017 10:14
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development September 16, 2017 10:14
Reduction, Cumulative fecundity and spawning March 20, 2017 17:52
Decrease, Population trajectory September 26, 2017 11:33
modulation, Unknown leads to Increased, HIF-1 alpha transcription December 03, 2016 16:38
Increased, HIF-1 alpha transcription leads to Increased, HIF-1 heterodimer December 03, 2016 16:38
Increased, HIF-1 heterodimer leads to Decreased, Aromatase (Cyp19a1) mRNA December 03, 2016 16:38
Decreased, Aromatase (Cyp19a1) mRNA leads to Reduction, 17beta-estradiol synthesis by ovarian granulosa cells December 03, 2016 16:38
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells leads to Reduction, Plasma 17beta-estradiol concentrations March 20, 2017 12:05
Reduction, Plasma 17beta-estradiol concentrations leads to Reduction, Vitellogenin synthesis in liver March 20, 2017 12:28
Reduction, Vitellogenin synthesis in liver leads to Reduction, Plasma vitellogenin concentrations March 20, 2017 12:58
Reduction, Plasma vitellogenin concentrations leads to Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development March 20, 2017 13:21
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development leads to Reduction, Cumulative fecundity and spawning March 20, 2017 13:35
Reduction, Cumulative fecundity and spawning leads to Decrease, Population trajectory March 20, 2017 13:49

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
modulation, Unknown modulation, Unknown

Key Events

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Title Short name
Increased, HIF-1 heterodimer Increased, HIF-1 heterodimer
Increased, HIF-1 alpha transcription Increased, HIF-1 alpha transcription
Decreased, Aromatase (Cyp19a1) mRNA Decreased, Aromatase (Cyp19a1) mRNA
Reduction, Plasma 17beta-estradiol concentrations Reduction, Plasma 17beta-estradiol concentrations
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Reduction, Vitellogenin synthesis in liver Reduction, Vitellogenin synthesis in liver
Reduction, Plasma vitellogenin concentrations Reduction, Plasma vitellogenin concentrations
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development

Adverse Outcome

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Title Short name
Reduction, Cumulative fecundity and spawning Reduction, Cumulative fecundity and spawning
Decrease, Population trajectory Decrease, Population trajectory

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
Adult, reproductively mature

Taxonomic Applicability

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Term Scientific Term Evidence Link
Pimephales promelas Pimephales promelas NCBI

Sex Applicability

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Sex Evidence
Female

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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