API

Relationship: 803

Title

?

Increased, HIF-1 alpha transcription leads to Increased, HIF-1 heterodimer

Upstream event

?

Increased, HIF-1 alpha transcription

Downstream event

?


Increased, HIF-1 heterodimer

Key Event Relationship Overview

?


AOPs Referencing Relationship

?

AOP Name Adjacency Weight of Evidence Quantitative Understanding
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription adjacent Low Low

Taxonomic Applicability

?

Sex Applicability

?

Life Stage Applicability

?

Key Event Relationship Description

?


Evidence Supporting this KER

?


Biological Plausibility

?

Empirical Evidence

?

Uncertainties and Inconsistencies

?

Quantitative Understanding of the Linkage

?


Response-response Relationship

?

Time-scale

?

Known modulating factors

?

Known Feedforward/Feedback loops influencing this KER

?

Domain of Applicability

?


References

?