API

Stressor: 48

Title

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Propylthiouracil

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Propylthiouracil DTXSID5021209 6-Propyl-2-thiouracil 51-52-5 KNAHARQHSZJURB-UHFFFAOYSA-N KNAHARQHSZJURB-UHFFFAOYSA-N

AOP Evidence

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Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation

There is no evidence text for this AOP



Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation

There is no evidence text for this AOP



Thyroperoxidase inhibition leading to altered amphibian metamorphosis

There is no evidence text for this AOP



Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation

There is no evidence text for this AOP



Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals

There is no evidence text for this AOP




Event Evidence

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Thyroperoxidase, Inhibition

There is no evidence text for this event.



Inhibition, Deiodinase 1

There is no evidence text for this event.



Thyroxine (T4) in serum, Decreased

6-n-propylthouracil is a classic positive control for inhibition of TPO



Thyroid hormone synthesis, Decreased

6-n-proylthiouracil is a common positive control



Thyroxine (T4) in neuronal tissue, Decreased

There is no evidence text for this event.



Hippocampal gene expression, Altered

There is no evidence text for this event.



Hippocampal anatomy, Altered

There is no evidence text for this event.



Hippocampal Physiology, Altered

There is no evidence text for this event.



Cognitive Function, Decreased

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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