API XML

Aop: 345

AOP Title

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Androgen receptor (AR) antagonism leading to decreased fertility in females

Short name:

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AR antagonism leading to decreased fertility

Graphical Representation

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Click to download graphical representation template

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Authors

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Eleftheria-Maria Panagiotou; Karolinska Institutet and Karolinska University Hospital, SE-14186 Stockholm, Sweden

Pauliina Damdimopoulou; Karolinska Institutet and Karolinska University Hospital, SE-14186 Stockholm, Sweden

Terje Svingen; National Food Institute, Technical University of Denmark, Kongens Lyngby, 2800 Denmark

Point of Contact

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Terje Svingen   (email point of contact)

Contributors

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  • Terje Svingen

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on October 13, 2020 10:27

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Revision dates for related pages

Page Revision Date/Time
Antagonism, Androgen receptor May 17, 2020 10:54
Decreased, Transcription of genes by AR August 07, 2020 06:53
Decreased fertility, Reduced number of oocytes ovulated December 03, 2016 16:37
Granulosa cell proliferation of gonadotropin-independent follicles, Reduced October 13, 2020 10:19
Flutamide November 29, 2016 18:42

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 26 Antagonism, Androgen receptor Antagonism, Androgen receptor
KE 286 Decreased, Transcription of genes by AR Decreased, Transcription of genes by AR
KE 1800 Granulosa cell proliferation of gonadotropin-independent follicles, Reduced Reduced granulosa cell proliferation
AO 972 Decreased fertility, Reduced number of oocytes ovulated Decreased fertility, Reduced number of oocytes ovulated

Relationships Between Two Key Events
(Including MIEs and AOs)

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Network View

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Stressors

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Name Evidence Term
Flutamide Moderate

Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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