Stressor: 137

Title

Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE). It can also include non-chemical prototypical stressors such as genetic or environmental factors. More help

Flutamide

Stressor Overview

A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP. More help

AOPs Including This Stressor

This table is automatically generated and lists the AOPs associated with this prototypical stressor. More help

AOP Name	Evidence
Androgen receptor (AR) antagonism leading to decreased fertility in females	Moderate
Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring
Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring

Chemical Table

A list of chemicals associated with a prototypical stressor. More help

Preferred name	DTXID	Casrn	jchem_inchi_key	indigo_inchi_key	User term
Flutamide	DTXSID7032004	13311-84-7	MKXKFYHWDHIYRV-UHFFFAOYSA-N	MKXKFYHWDHIYRV-UHFFFAOYSA-N	Flutamide

References

List of the literature that was cited for this prototypical stressor. More help

Foster & Harris (2005), Toxicol Sci 85:1024-1032; doi: 10.1093/toxsci/kfi159

Hass et al (2007), Environ Health Perspect 115(suppl 1):122-128; doi: 10.1289/ehp.0360

Kita et al (2016), Toxicology 368-369:152-161; doi: 10.1016/j.tox.2016.08.021

McIntyre et al (2001), Toxicol Sci 62:236-249; doi: 10.1093/toxsci/62.2.236

Mylchreest et al (1999), Toxicol Appl Pharmacol 156:81-95; doi: 10.1006/taap.1999.8643

Scott et al (2007), Endocrinology 148:2027-2036; doi: 10.1210/en.2006-1622

Simard et al (1986), Mol Cell Endocrinol 44:261-270; doi: 10.1016/0303-7207(86)90132-2