API XML

Aop: 361

AOP Title

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Sulfonylureareceptor binding leading to mortality

Short name:

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SUR binding leading to mortality

Graphical Representation

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Click to download graphical representation template

Authors

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Simon Schmid 1,2, You Song 1, and Knut Erik Tollefsen 1,2

1 Norwegian Institute for Water Research (NIVA), Section of Ecotoxicology and Risk Assessment, Gaustadalléen 21, N-0349, Oslo, Norway

2 Faculty of Environmental Science and Resource Management, Department of Environmental Sciences (IMV), Norwegian University of Life Sciences (NMBU), N-1432, Ås, Norway

Point of Contact

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Simon Schmid   (email point of contact)

Contributors

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  • Simon Schmid
  • You Song
  • Knut Erik Tollefsen

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on October 23, 2020 03:52

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Revision dates for related pages

Page Revision Date/Time
Increase, Sulfonylurea receptor binding May 24, 2018 16:09
Increase, Cell membrane depolarization May 24, 2018 16:20
Increase, Opening of voltage-dependent calcium channel May 24, 2018 16:19
Decrease, Cuticular chitin content November 11, 2020 03:25
Increase, Premature molting October 26, 2020 06:21
Increase, Mortality October 26, 2020 05:18
Increase, SUR binding leads to Increase, Cell membrane depolarization May 24, 2018 16:22
Increase, Cell membrane depolarization leads to Increase, Opening of voltage-dependent calcium channel May 24, 2018 16:23
Increase, Opening of voltage-dependent calcium channel leads to Decrease, Cuticular chitin content May 24, 2018 16:23
Decrease, Cuticular chitin content leads to Increase, Premature molting October 26, 2020 06:18
Increase, Premature molting leads to Increase, Mortality October 26, 2020 06:12

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1525 Increase, Sulfonylurea receptor binding Increase, SUR binding
KE 1527 Increase, Cell membrane depolarization Increase, Cell membrane depolarization
KE 1526 Increase, Opening of voltage-dependent calcium channel Increase, Opening of voltage-dependent calcium channel
KE 1523 Decrease, Cuticular chitin content Decrease, Cuticular chitin content
KE 1524 Increase, Premature molting Increase, Premature molting
AO 350 Increase, Mortality Increase, Mortality

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, SUR binding leads to Increase, Cell membrane depolarization adjacent Low Low
Increase, Cell membrane depolarization leads to Increase, Opening of voltage-dependent calcium channel adjacent Low Low
Increase, Opening of voltage-dependent calcium channel leads to Decrease, Cuticular chitin content adjacent Low Low
Decrease, Cuticular chitin content leads to Increase, Premature molting adjacent Moderate Moderate
Increase, Premature molting leads to Increase, Mortality adjacent High High

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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