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Aop: 277
AOP Title
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Inhibition of IL-1 signaling
Short name:
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IL-1 inhibition
Graphical Representation
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Click to download graphical representation template
Authors
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Yutaka Kimura (1) Setsuya Aiba (1)
(1) Depertment of Dermatology, Tohoku University Graduate School of Medicine
Corresponding author: Setsuya Aiba
Point of Contact
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Yutaka Kimura
(email point of contact)
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Status
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| Author status |
OECD status |
OECD project |
SAAOP status |
| Under development: Not open for comment. Do not cite |
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This AOP was last modified on January 06, 2019 20:02
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Revision dates for related pages
| Page |
Revision Date/Time |
| Increase, Increased susceptibility to infection |
December 03, 2016 16:33 |
| Blocking of IL-1R |
December 26, 2018 00:34 |
| Decreased IL-1 production |
December 24, 2018 23:47 |
| Impaired IL-1 signaling |
December 24, 2018 23:52 |
| Suppressed MyD88 |
January 06, 2019 19:58 |
| Blocking of IL-1R leads to Impaired IL-1 signaling |
December 24, 2018 23:56 |
| Decreased IL-1 production leads to Impaired IL-1 signaling |
December 25, 2018 00:01 |
| Impaired IL-1 signaling leads to Suppressed MyD88 |
January 06, 2019 20:02 |
| Suppressed MyD88 leads to Increase, Increased susceptibility to infection |
January 06, 2019 20:02 |
Abstract
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Background (optional)
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Summary of the AOP
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Events: Molecular Initiating Events (MIE)
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Key Events (KE)
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Adverse Outcomes (AO)
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Relationships Between Two Key Events
(Including MIEs and AOs)
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Adjacency |
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Network View
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Stressors
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Life Stage Applicability
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Taxonomic Applicability
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Sex Applicability
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Overall Assessment of the AOP
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Domain of Applicability
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Essentiality of the Key Events
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Evidence Assessment
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Quantitative Understanding
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Considerations for Potential Applications of the AOP (optional)
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References
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