API XML

Aop: 277

AOP Title

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Inhibition of IL-1 signaling

Short name:

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IL-1 inhibition

Graphical Representation

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Click to download graphical representation template

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Authors

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Yutaka Kimura (1) Setsuya Aiba (1) 

(1) Depertment of Dermatology, Tohoku University Graduate School of Medicine

Corresponding author: Setsuya Aiba

Point of Contact

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Yutaka Kimura   (email point of contact)

Contributors

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  • Yutaka Kimura

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on January 06, 2019 20:02

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Revision dates for related pages

Page Revision Date/Time
Increase, Increased susceptibility to infection December 03, 2016 16:33
Blocking of IL-1R December 26, 2018 00:34
Decreased IL-1 production December 24, 2018 23:47
Impaired IL-1 signaling December 24, 2018 23:52
Suppressed MyD88 January 06, 2019 19:58
Blocking of IL-1R leads to Impaired IL-1 signaling December 24, 2018 23:56
Decreased IL-1 production leads to Impaired IL-1 signaling December 25, 2018 00:01
Impaired IL-1 signaling leads to Suppressed MyD88 January 06, 2019 20:02
Suppressed MyD88 leads to Increase, Increased susceptibility to infection January 06, 2019 20:02

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1570 Blocking of IL-1R Blocking of IL-1R
MIE 1571 Decreased IL-1 production Decreased IL-1 production
MIE 1572 Impaired IL-1 signaling Impaired IL-1 signaling
KE 1573 Suppressed MyD88 Suppressed MyD88
AO 986 Increase, Increased susceptibility to infection Increase, Increased susceptibility to infection

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Blocking of IL-1R leads to Impaired IL-1 signaling adjacent High High
Decreased IL-1 production leads to Impaired IL-1 signaling adjacent High High
Impaired IL-1 signaling leads to Suppressed MyD88 adjacent High High
Suppressed MyD88 leads to Increase, Increased susceptibility to infection adjacent High High

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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