API

Stressor: 492

Title

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Dexamethasone

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Dexamethasone DTXSID3020384 Dexamethasone 50-02-2 UREBDLICKHMUKA-CXSFZGCWSA-N UREBDLICKHMUKA-CXSFZGCWSA-N

AOP Evidence

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Glucocorticoid Receptor activation leading to hepatic steatosis

There is no evidence text for this AOP




Event Evidence

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Decreased IL-1 production

There is no evidence text for this event.



Impaired IL-1 signaling

There is no evidence text for this event.



Impaired T cell activation

There is no evidence text for this event.



Impaired Ab production

There is no evidence text for this event.



Suppression, IL-2 and IL-4 production

There is no evidence text for this event.



decrease, male anogenital distance

Dexamethasone has been shown to cause decreased male AGD in rats following intrauterine exposure to 0.1 mg/kg bw/day (Van den Driesche et al, 2012).




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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