API

Aop: 130

AOP Title

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Phospholipase A inhibitors lead to hepatotoxicity

Short name:

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Phospholipase A inhibitors

Authors

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Point of Contact

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Seokjoo Yoon

Contributors

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  • Seokjoo Yoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.39 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Inhibition, Phospholipase A December 03, 2016 16:37
Damage, Lipid bilayer December 03, 2016 16:37
Disturbance, Lysosomal function September 16, 2017 10:16
Injury, Mitochondria September 16, 2017 10:16
Occurrence, Cytoplasmic vacuolization (hepatocyte) September 16, 2017 10:16
Occurrence, Ballooning degeneration (hepatocyte) September 16, 2017 10:16
Occurrence, Cytoplasmic vacuolization (kupffer cell) September 16, 2017 10:16
Induction, Microvesicular fat December 03, 2016 16:37
Formation, Mallory body December 03, 2016 16:37
Formation, Liver fibrosis September 16, 2017 10:16
Occurrence, Cytoplasmic vacuolization (Bile duct cell) September 16, 2017 10:16
Inhibition, Phospholipase A leads to Damage, Lipid bilayer December 03, 2016 16:38
Inhibition, Phospholipase A leads to Disturbance, Lysosomal function December 03, 2016 16:38
Inhibition, Phospholipase A leads to Injury, Mitochondria December 03, 2016 16:38
Damage, Lipid bilayer leads to Occurrence, Cytoplasmic vacuolization (hepatocyte) December 03, 2016 16:38
Damage, Lipid bilayer leads to Occurrence, Ballooning degeneration (hepatocyte) December 03, 2016 16:38
Damage, Lipid bilayer leads to Occurrence, Cytoplasmic vacuolization (Bile duct cell) December 03, 2016 16:38
Damage, Lipid bilayer leads to Occurrence, Cytoplasmic vacuolization (kupffer cell) December 03, 2016 16:38
Disturbance, Lysosomal function leads to Occurrence, Cytoplasmic vacuolization (hepatocyte) December 03, 2016 16:38
Disturbance, Lysosomal function leads to Occurrence, Ballooning degeneration (hepatocyte) December 03, 2016 16:38
Disturbance, Lysosomal function leads to Occurrence, Cytoplasmic vacuolization (Bile duct cell) December 03, 2016 16:38
Disturbance, Lysosomal function leads to Occurrence, Cytoplasmic vacuolization (kupffer cell) December 03, 2016 16:38
Injury, Mitochondria leads to Occurrence, Cytoplasmic vacuolization (hepatocyte) December 03, 2016 16:38
Injury, Mitochondria leads to Occurrence, Ballooning degeneration (hepatocyte) December 03, 2016 16:38
Injury, Mitochondria leads to Occurrence, Cytoplasmic vacuolization (Bile duct cell) December 03, 2016 16:38
Injury, Mitochondria leads to Occurrence, Cytoplasmic vacuolization (kupffer cell) December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (hepatocyte) leads to Induction, Microvesicular fat December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (hepatocyte) leads to Formation, Mallory body December 03, 2016 16:38
Occurrence, Ballooning degeneration (hepatocyte) leads to Induction, Microvesicular fat December 03, 2016 16:38
Occurrence, Ballooning degeneration (hepatocyte) leads to Formation, Mallory body December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (Bile duct cell) leads to Induction, Microvesicular fat December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (Bile duct cell) leads to Formation, Mallory body December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (kupffer cell) leads to Induction, Microvesicular fat December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (kupffer cell) leads to Formation, Mallory body December 03, 2016 16:38
Induction, Microvesicular fat leads to Formation, Liver fibrosis December 03, 2016 16:38
Formation, Mallory body leads to Formation, Liver fibrosis December 03, 2016 16:38

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Inhibition, Phospholipase A Inhibition, Phospholipase A

Key Events

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Title Short name
Damage, Lipid bilayer Damage, Lipid bilayer
Disturbance, Lysosomal function Disturbance, Lysosomal function
Injury, Mitochondria Injury, Mitochondria
Occurrence, Cytoplasmic vacuolization (hepatocyte) Occurrence, Cytoplasmic vacuolization (hepatocyte)
Occurrence, Ballooning degeneration (hepatocyte) Occurrence, Ballooning degeneration (hepatocyte)
Occurrence, Cytoplasmic vacuolization (kupffer cell) Occurrence, Cytoplasmic vacuolization (kupffer cell)
Induction, Microvesicular fat Induction, Microvesicular fat
Formation, Mallory body Formation, Mallory body
Occurrence, Cytoplasmic vacuolization (Bile duct cell) Occurrence, Cytoplasmic vacuolization (Bile duct cell)

Adverse Outcome

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Title Short name
Formation, Liver fibrosis Formation, Liver fibrosis

Relationships Between Two Key Events (Including MIEs and AOs)

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Title Directness Evidence Quantitative Understanding
Inhibition, Phospholipase A leads to Damage, Lipid bilayer Directly leads to Strong
Inhibition, Phospholipase A leads to Disturbance, Lysosomal function Directly leads to Strong
Inhibition, Phospholipase A leads to Injury, Mitochondria Directly leads to Strong
Damage, Lipid bilayer leads to Occurrence, Cytoplasmic vacuolization (hepatocyte) Directly leads to Weak
Damage, Lipid bilayer leads to Occurrence, Ballooning degeneration (hepatocyte) Directly leads to Weak
Damage, Lipid bilayer leads to Occurrence, Cytoplasmic vacuolization (Bile duct cell) Directly leads to Weak
Damage, Lipid bilayer leads to Occurrence, Cytoplasmic vacuolization (kupffer cell) Directly leads to Weak
Disturbance, Lysosomal function leads to Occurrence, Cytoplasmic vacuolization (hepatocyte) Directly leads to Weak
Disturbance, Lysosomal function leads to Occurrence, Ballooning degeneration (hepatocyte) Directly leads to Weak
Disturbance, Lysosomal function leads to Occurrence, Cytoplasmic vacuolization (Bile duct cell) Directly leads to Weak
Disturbance, Lysosomal function leads to Occurrence, Cytoplasmic vacuolization (kupffer cell) Directly leads to Weak
Injury, Mitochondria leads to Occurrence, Cytoplasmic vacuolization (hepatocyte) Directly leads to Weak
Injury, Mitochondria leads to Occurrence, Ballooning degeneration (hepatocyte) Directly leads to Weak
Injury, Mitochondria leads to Occurrence, Cytoplasmic vacuolization (Bile duct cell) Directly leads to Weak
Injury, Mitochondria leads to Occurrence, Cytoplasmic vacuolization (kupffer cell) Directly leads to Weak
Occurrence, Cytoplasmic vacuolization (hepatocyte) leads to Induction, Microvesicular fat Directly leads to Weak
Occurrence, Cytoplasmic vacuolization (hepatocyte) leads to Formation, Mallory body Directly leads to Weak
Occurrence, Ballooning degeneration (hepatocyte) leads to Induction, Microvesicular fat Directly leads to Weak
Occurrence, Ballooning degeneration (hepatocyte) leads to Formation, Mallory body Directly leads to Weak
Occurrence, Cytoplasmic vacuolization (Bile duct cell) leads to Induction, Microvesicular fat Directly leads to Weak
Occurrence, Cytoplasmic vacuolization (Bile duct cell) leads to Formation, Mallory body Directly leads to Weak
Occurrence, Cytoplasmic vacuolization (kupffer cell) leads to Induction, Microvesicular fat Directly leads to Weak
Occurrence, Cytoplasmic vacuolization (kupffer cell) leads to Formation, Mallory body Directly leads to Weak
Induction, Microvesicular fat leads to Formation, Liver fibrosis Directly leads to Strong
Formation, Mallory body leads to Formation, Liver fibrosis Directly leads to Strong

Network View

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Life Stage Applicability

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Life stage Evidence
1 to < 3 months Strong
Adults Strong

Taxonomic Applicability

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Term Scientific Term Evidence Link
Sprague-Dawley Sprague-Dawley Strong NCBI
Homo sapiens Homo sapiens Strong NCBI

Sex Applicability

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Sex Evidence
Male Strong
Unspecific Weak

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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