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Aop: 130

AOP Title

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Phospholipase A inhibitors lead to hepatotoxicity

Short name:

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Phospholipase A inhibitors

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Seokjoo Yoon   (email point of contact)

Contributors

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  • Seokjoo Yoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.39 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
Inhibition, Phospholipase A December 03, 2016 16:37
Damage, Lipid bilayer December 03, 2016 16:37
Disturbance, Lysosomal function September 16, 2017 10:16
Injury, Mitochondria September 16, 2017 10:16
Occurrence, Cytoplasmic vacuolization (hepatocyte) September 16, 2017 10:16
Occurrence, Ballooning degeneration (hepatocyte) September 16, 2017 10:16
Occurrence, Cytoplasmic vacuolization (kupffer cell) September 16, 2017 10:16
Induction, Microvesicular fat December 03, 2016 16:37
Formation, Mallory body December 03, 2016 16:37
Formation, Liver fibrosis September 16, 2017 10:16
Occurrence, Cytoplasmic vacuolization (Bile duct cell) September 16, 2017 10:16
Inhibition, Phospholipase A leads to Damage, Lipid bilayer December 03, 2016 16:38
Inhibition, Phospholipase A leads to Disturbance, Lysosomal function December 03, 2016 16:38
Inhibition, Phospholipase A leads to Injury, Mitochondria December 03, 2016 16:38
Damage, Lipid bilayer leads to Occurrence, Cytoplasmic vacuolization (hepatocyte) December 03, 2016 16:38
Damage, Lipid bilayer leads to Occurrence, Ballooning degeneration (hepatocyte) December 03, 2016 16:38
Damage, Lipid bilayer leads to Occurrence, Cytoplasmic vacuolization (Bile duct cell) December 03, 2016 16:38
Damage, Lipid bilayer leads to Occurrence, Cytoplasmic vacuolization (kupffer cell) December 03, 2016 16:38
Disturbance, Lysosomal function leads to Occurrence, Cytoplasmic vacuolization (hepatocyte) December 03, 2016 16:38
Disturbance, Lysosomal function leads to Occurrence, Ballooning degeneration (hepatocyte) December 03, 2016 16:38
Disturbance, Lysosomal function leads to Occurrence, Cytoplasmic vacuolization (Bile duct cell) December 03, 2016 16:38
Disturbance, Lysosomal function leads to Occurrence, Cytoplasmic vacuolization (kupffer cell) December 03, 2016 16:38
Injury, Mitochondria leads to Occurrence, Cytoplasmic vacuolization (hepatocyte) December 03, 2016 16:38
Injury, Mitochondria leads to Occurrence, Ballooning degeneration (hepatocyte) December 03, 2016 16:38
Injury, Mitochondria leads to Occurrence, Cytoplasmic vacuolization (Bile duct cell) December 03, 2016 16:38
Injury, Mitochondria leads to Occurrence, Cytoplasmic vacuolization (kupffer cell) December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (hepatocyte) leads to Induction, Microvesicular fat December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (hepatocyte) leads to Formation, Mallory body December 03, 2016 16:38
Occurrence, Ballooning degeneration (hepatocyte) leads to Induction, Microvesicular fat December 03, 2016 16:38
Occurrence, Ballooning degeneration (hepatocyte) leads to Formation, Mallory body December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (Bile duct cell) leads to Induction, Microvesicular fat December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (Bile duct cell) leads to Formation, Mallory body December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (kupffer cell) leads to Induction, Microvesicular fat December 03, 2016 16:38
Occurrence, Cytoplasmic vacuolization (kupffer cell) leads to Formation, Mallory body December 03, 2016 16:38
Induction, Microvesicular fat leads to Formation, Liver fibrosis December 03, 2016 16:38
Formation, Mallory body leads to Formation, Liver fibrosis December 03, 2016 16:38

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 828 Inhibition, Phospholipase A Inhibition, Phospholipase A
2 KE 829 Damage, Lipid bilayer Damage, Lipid bilayer
3 KE 831 Disturbance, Lysosomal function Disturbance, Lysosomal function
4 KE 832 Injury, Mitochondria Injury, Mitochondria
5 KE 833 Occurrence, Cytoplasmic vacuolization (hepatocyte) Occurrence, Cytoplasmic vacuolization (hepatocyte)
6 KE 835 Occurrence, Ballooning degeneration (hepatocyte) Occurrence, Ballooning degeneration (hepatocyte)
7 KE 837 Occurrence, Cytoplasmic vacuolization (kupffer cell) Occurrence, Cytoplasmic vacuolization (kupffer cell)
8 KE 838 Induction, Microvesicular fat Induction, Microvesicular fat
9 KE 839 Formation, Mallory body Formation, Mallory body
10 KE 836 Occurrence, Cytoplasmic vacuolization (Bile duct cell) Occurrence, Cytoplasmic vacuolization (Bile duct cell)
11 AO 840 Formation, Liver fibrosis Formation, Liver fibrosis

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Inhibition, Phospholipase A leads to Damage, Lipid bilayer adjacent High
Inhibition, Phospholipase A leads to Disturbance, Lysosomal function adjacent High
Inhibition, Phospholipase A leads to Injury, Mitochondria adjacent High
Damage, Lipid bilayer leads to Occurrence, Cytoplasmic vacuolization (hepatocyte) adjacent Low
Damage, Lipid bilayer leads to Occurrence, Ballooning degeneration (hepatocyte) adjacent Low
Damage, Lipid bilayer leads to Occurrence, Cytoplasmic vacuolization (Bile duct cell) adjacent Low
Damage, Lipid bilayer leads to Occurrence, Cytoplasmic vacuolization (kupffer cell) adjacent Low
Disturbance, Lysosomal function leads to Occurrence, Cytoplasmic vacuolization (hepatocyte) adjacent Low
Disturbance, Lysosomal function leads to Occurrence, Ballooning degeneration (hepatocyte) adjacent Low
Disturbance, Lysosomal function leads to Occurrence, Cytoplasmic vacuolization (Bile duct cell) adjacent Low
Disturbance, Lysosomal function leads to Occurrence, Cytoplasmic vacuolization (kupffer cell) adjacent Low
Injury, Mitochondria leads to Occurrence, Cytoplasmic vacuolization (hepatocyte) adjacent Low
Injury, Mitochondria leads to Occurrence, Ballooning degeneration (hepatocyte) adjacent Low
Injury, Mitochondria leads to Occurrence, Cytoplasmic vacuolization (Bile duct cell) adjacent Low
Injury, Mitochondria leads to Occurrence, Cytoplasmic vacuolization (kupffer cell) adjacent Low
Occurrence, Cytoplasmic vacuolization (hepatocyte) leads to Induction, Microvesicular fat adjacent Low
Occurrence, Cytoplasmic vacuolization (hepatocyte) leads to Formation, Mallory body adjacent Low
Occurrence, Ballooning degeneration (hepatocyte) leads to Induction, Microvesicular fat adjacent Low
Occurrence, Ballooning degeneration (hepatocyte) leads to Formation, Mallory body adjacent Low
Occurrence, Cytoplasmic vacuolization (Bile duct cell) leads to Induction, Microvesicular fat adjacent Low
Occurrence, Cytoplasmic vacuolization (Bile duct cell) leads to Formation, Mallory body adjacent Low
Occurrence, Cytoplasmic vacuolization (kupffer cell) leads to Induction, Microvesicular fat adjacent Low
Occurrence, Cytoplasmic vacuolization (kupffer cell) leads to Formation, Mallory body adjacent Low
Induction, Microvesicular fat leads to Formation, Liver fibrosis adjacent High
Formation, Mallory body leads to Formation, Liver fibrosis adjacent High

Network View

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Stressors

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Life Stage Applicability

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Life stage Evidence
1 to < 3 months High
Adults High

Taxonomic Applicability

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Term Scientific Term Evidence Link
Sprague-Dawley Sprague-Dawley High NCBI
Homo sapiens Homo sapiens High NCBI

Sex Applicability

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Sex Evidence
Male High
Unspecific Low

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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