API

Aop: 117

AOP Title

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Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)

Short name:

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AR- HCC

Authors

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Cancer AOP Workgroup. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)

Point of Contact

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Charles Wood

Contributors

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  • Charles Wood

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.26 Included in OECD Work Plan


This AOP was last modified on June 06, 2017 08:43

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Revision dates for related pages

Page Revision Date/Time
Activation, Androgen receptor December 03, 2016 16:37
Increase, Mitogenic cell proliferation (hepatocytes) September 16, 2017 10:16
Increase, Preneoplastic foci (hepatocytes) September 16, 2017 10:16
Increase, Adenomas/carcinomas (hepatocellular) September 16, 2017 10:16
Activation, Androgen receptor leads to Increase, Mitogenic cell proliferation (hepatocytes) December 03, 2016 16:38
Increase, Mitogenic cell proliferation (hepatocytes) leads to Increase, Preneoplastic foci (hepatocytes) February 14, 2017 17:05
Increase, Preneoplastic foci (hepatocytes) leads to Increase, Adenomas/carcinomas (hepatocellular) February 15, 2017 10:20

Abstract

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This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.


Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Activation, Androgen receptor Activation, Androgen receptor

Key Events

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Title Short name
Increase, Mitogenic cell proliferation (hepatocytes) Increase, Mitogenic cell proliferation (hepatocytes)
Increase, Preneoplastic foci (hepatocytes) Increase, Preneoplastic foci (hepatocytes)

Adverse Outcome

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Title Short name
Increase, Adenomas/carcinomas (hepatocellular) Increase, Adenomas/carcinomas (hepatocellular)

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Mus musculus Mus musculus NCBI
Rattus norvegicus Rattus norvegicus NCBI

Sex Applicability

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Sex Evidence
Male
Female

Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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NTP (National Toxicology Program). (September 2010). Toxicology and Carcinogenesis Studies of Androstenedione in F344/N Rats and B6C3F1 Mice (Vol. NTP TR 560).