API

Event: 719

Key Event Title

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Increase, Adenomas/carcinomas (hepatocellular)

Short name

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Increase, Adenomas/carcinomas (hepatocellular)

Biological Context

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Level of Biological Organization
Tissue


Organ term

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Organ term
liver


Key Event Components

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Process Object Action
Adenoma increased
Carcinoma increased
hepatocellular carcinoma Adenoma increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
CAR activation- Hepatocellular tumors AdverseOutcome
PDK inhibition- HCC AdverseOutcome
AR- HCC AdverseOutcome
Chronic cytotoxicity- HCC AdverseOutcome
PPARalpha-dependent liver cancer AdverseOutcome

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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How It Is Measured or Detected

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Domain of Applicability

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Regulatory Significance of the Adverse Outcome

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References

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