API

Event: 51

Key Event Title

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Inhibition, Ca++ ATPase

Short name

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Inhibition, Ca++ ATPase

Key Event Component

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Process Object Action
calcium-transporting ATPase activity calcium ion-transporting ATPase complex decreased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
Calcium-mediated neuronal ROS production and energy imbalance MolecularInitiatingEvent

Stressors

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Name
Lead(II)

Level of Biological Organization

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Biological Organization
Molecular

Cell term

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Cell term
eukaryotic cell


Organ term

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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How This Key Event Works

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Pb(II) has been shown to decrease Ca++ ATPase activity, leading to an increase in intracellular calcium. It is not known exactly how this works; however, it may be through Pb++ competition with Ca++ [1]


How It Is Measured or Detected

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Evidence Supporting Taxonomic Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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  1. He, T, et al. 2009. Chronic lead exposure alters presynaptic calcium regulation and synaptic facilitation in Drosophila larvae. NeuroToxicology 30(5): 777-84.