API

Aop: 96

AOP Title

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Axonal sodium channel modulation leading to acute mortality

Short name:

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sodium channel modulation

Authors

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Kellie Fay

Point of Contact

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Kellie Fay

Contributors

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  • Kellie Fay

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on December 03, 2016 16:37

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Revision dates for related pages

Page Revision Date/Time
modulation, sodium channel September 16, 2017 10:15
prolonged, Depolarization of neuronal membrane September 16, 2017 10:15
Overactivation, Neuronotransmitter release September 16, 2017 10:15
Overactivation, muscle contraction September 16, 2017 10:15
Increased, Ataxia, paralysis, or hyperactivity September 16, 2017 10:15
Increased, Mortality May 15, 2017 11:34
modulation, sodium channel leads to prolonged, Depolarization of neuronal membrane December 03, 2016 16:37
prolonged, Depolarization of neuronal membrane leads to Overactivation, Neuronotransmitter release December 03, 2016 16:37
Overactivation, Neuronotransmitter release leads to Overactivation, muscle contraction December 03, 2016 16:37
Overactivation, muscle contraction leads to Increased, Ataxia, paralysis, or hyperactivity December 03, 2016 16:37
Increased, Ataxia, paralysis, or hyperactivity leads to Increased, Mortality December 03, 2016 16:37

Abstract

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The voltage-gated sodium channels present on neuronal axons are the primary molecular target of pyrethroid insecticides. These chemicals selectively bind open sodium channels, allowing continuous entry of sodium ions into the cell. This hyperdepolarization of the nerve membrane results in a prolonged tail current, uncontrolled firing and neurotransmitter release. Ultimately, ataxia, paralysis and death result.


Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
modulation, sodium channel modulation, sodium channel

Key Events

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Title Short name
prolonged, Depolarization of neuronal membrane prolonged, Depolarization of neuronal membrane
Overactivation, Neuronotransmitter release Overactivation, Neuronotransmitter release
Overactivation, muscle contraction Overactivation, muscle contraction
Increased, Ataxia, paralysis, or hyperactivity Increased, Ataxia, paralysis, or hyperactivity

Adverse Outcome

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Title Short name
Increased, Mortality Increased, Mortality

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Life stage Evidence
During development and at adulthood

Taxonomic Applicability

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Term Scientific Term Evidence Link
insects insects NCBI
fish fish NCBI

Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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