API

Event: 1558

Key Event Title

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Collagen production, reduced

Short name

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Reduced collagen production

Biological Context

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Level of Biological Organization
Tissue


Organ term

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Key Event Components

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Process Object Action

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
HDAC inhibition leads to impeded craniofacial development KeyEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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Post-migratory cranial NCCs differentiate to give rise to chondrocytes which secrete collagen in order to form the cartilage structures which form the precursors of bony facial features (Bhatt et al., 2013).


How It Is Measured or Detected

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Collagen expression is considered a marker for NCC differentiation into chondrocytes (Bhatt et al., 2013) and can be assessed in vivo by fluorescent microscopy using fluorescent collagen reporter zebrafish lines (Hammond and Schulte-Merker, 2009).


Domain of Applicability

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References

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Bhatt, S., Diaz, R., Trainor, P. a, Wu, D.K., Kelley, M.W., Tam, P.L., et al. (2013), Cold Spring Harb Perspect Biol 5: 1–20.

Hammond, C.L., and Schulte-Merker, S. (2009), Development 136: 3991–4000.