To the extent possible under law, AOP-Wiki has waived all copyright and related or neighboring rights to KE:1558
Key Event Title
Collagen production, reduced
Key Event Components
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP||Point of Contact||Author Status||OECD Status|
|HDAC inhibition leads to impeded craniofacial development||KeyEvent||Marvin Martens (send email)||Under development: Not open for comment. Do not cite|
Key Event Description
Post-migratory cranial NCCs differentiate to give rise to chondrocytes which secrete collagen in order to form the cartilage structures which form the precursors of bony facial features (Bhatt et al., 2013).
How It Is Measured or Detected
Collagen expression is considered a marker for NCC differentiation into chondrocytes (Bhatt et al., 2013) and can be assessed in vivo by fluorescent microscopy using fluorescent collagen reporter zebrafish lines (Hammond and Schulte-Merker, 2009).
Domain of Applicability
Bhatt, S., Diaz, R., Trainor, P. a, Wu, D.K., Kelley, M.W., Tam, P.L., et al. (2013), Cold Spring Harb Perspect Biol 5: 1–20.
Hammond, C.L., and Schulte-Merker, S. (2009), Development 136: 3991–4000.