API

Event: 619

Key Event Title

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Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)

Short name

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Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)

Biological Context

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Level of Biological Organization
Molecular

Cell term

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Cell term
motor neuron


Organ term

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Key Event Components

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Process Object Action
neurotransmitter reuptake sodium-dependent serotonin transporter decreased
serotonin uptake sodium-dependent serotonin transporter decreased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
5-HTT block to population decline MolecularInitiatingEvent
5-HTT block to incr. predation MolecularInitiatingEvent
5-HTT leading to population increase MolecularInitiatingEvent
5-HTT leading to population decline MolecularInitiatingEvent
5-HTT inhibition leading to population increase MolecularInitiatingEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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Inhibitors of the serotonin reuptake transporter (SERT; 5-hydroxytryptamine transporter; 5-HTT) block the reuptake of the neurotransmitter serotonin, increasing its residence time in synapses.


How It Is Measured or Detected

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Toxcast assays that target the serotonin transporter (5-HTT; SERT) gene SLC6A4 include: NVS_TR_rSERT,NVS_TR_rSERT.


Domain of Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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