API

Aop: 204

AOP Title

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5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase

Short name:

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5-HTT inhibition leading to population increase

Authors

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Point of Contact

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Kellie Fay

Contributors

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  • Kellie Fay

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on January 13, 2017 16:24

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Revision dates for related pages

Page Revision Date/Time
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) September 16, 2017 10:15
Increased, valve movement December 03, 2016 16:37
Increase, cilia movement January 13, 2017 16:27
Induced parturition January 13, 2017 15:40
increased mantel display January 13, 2017 15:39
Increased, Reproductive Success December 03, 2016 16:37
Increased, Population December 03, 2016 16:37
Increased, serotonin (5-HT) September 16, 2017 10:15
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Increased, valve movement January 13, 2017 11:18
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Increase, cilia movement January 13, 2017 15:43
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to increased mantel display January 13, 2017 15:44
increased mantel display leads to Induced parturition January 13, 2017 15:49
Increased, Reproductive Success leads to Increased, Population December 03, 2016 16:38
Induced parturition leads to Increased, Reproductive Success January 13, 2017 16:48
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Increased, serotonin (5-HT) December 03, 2016 16:37
Increased, serotonin (5-HT) leads to Increased, valve movement January 17, 2017 01:02
Increased, valve movement leads to Induced parturition January 30, 2017 12:23
Increase, cilia movement leads to Induced parturition January 30, 2017 12:24
Increased, serotonin (5-HT) leads to increased mantel display January 30, 2017 12:25
Increased, serotonin (5-HT) leads to Increase, cilia movement January 30, 2017 12:20

Abstract

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Anti-depressants such as fluoxetine inhibit the reuptake of 5-HT by blocking the 5-HTT, causing an increase in serotonin levels at neural junctions.  Movement-related endpoints in molluscs may be highly sensitive to 5-HTT inhibition, empirical evidence also supports a putative AO for reproductive health because serotonin is reported to control oocyte maturation, spawning and glochidia release (Ram 1993, Bringolf 2010, Meechonkit 2010,Lazarra 2012). Exposure of native freshwater mussels to fluoxetine induced premature release of glochidia resulting in non-viable larvae (Bringolf 2010), however most reports indicate increased serotinergic signaling results in the release of either viable gametes or glochidia.  Release is, in part, dependent on the water pumping rate and coordination with cilia, at least in some bivalves.   


Background (optional)

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Summary of the AOP

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Stressors

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Molecular Initiating Event

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Title Short name
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)

Key Events

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Title Short name
Increased, valve movement Increased, valve movement
Increase, cilia movement Increase, cilia movement
Induced parturition Induced parturition
increased mantel display increased mantel display
Increased, serotonin (5-HT) Increased, serotonin (5-HT)

Adverse Outcome

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Title Short name
Increased, Reproductive Success Increased, Reproductive Success
Increased, Population Increased, Population

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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