API XML

Aop: 204

AOP Title

?


5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase

Short name:

?

5-HTT inhibition leading to population increase

Graphical Representation

?

Click to download graphical representation template

Authors

?


Point of Contact

?


Kellie Fay   (email point of contact)

Contributors

?


  • Kellie Fay

Status

?

Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

?

Revision dates for related pages

Page Revision Date/Time
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) September 16, 2017 10:15
Increased, valve movement December 03, 2016 16:37
Increase, cilia movement January 13, 2017 16:27
Induced parturition January 13, 2017 15:40
increased mantel display January 13, 2017 15:39
Increased, Reproductive Success December 03, 2016 16:37
Increased, Population December 03, 2016 16:37
Increased, serotonin (5-HT) September 16, 2017 10:15
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Increased, valve movement January 13, 2017 11:18
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Increase, cilia movement January 13, 2017 15:43
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to increased mantel display January 13, 2017 15:44
increased mantel display leads to Induced parturition January 13, 2017 15:49
Increased, Reproductive Success leads to Increased, Population December 03, 2016 16:38
Induced parturition leads to Increased, Reproductive Success January 13, 2017 16:48
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Increased, serotonin (5-HT) December 03, 2016 16:37
Increased, serotonin (5-HT) leads to Increased, valve movement January 17, 2017 01:02
Increased, valve movement leads to Induced parturition January 30, 2017 12:23
Increase, cilia movement leads to Induced parturition January 30, 2017 12:24
Increased, serotonin (5-HT) leads to increased mantel display January 30, 2017 12:25
Increased, serotonin (5-HT) leads to Increase, cilia movement January 30, 2017 12:20

Abstract

?


Anti-depressants such as fluoxetine inhibit the reuptake of 5-HT by blocking the 5-HTT, causing an increase in serotonin levels at neural junctions.  Movement-related endpoints in molluscs may be highly sensitive to 5-HTT inhibition, empirical evidence also supports a putative AO for reproductive health because serotonin is reported to control oocyte maturation, spawning and glochidia release (Ram 1993, Bringolf 2010, Meechonkit 2010,Lazarra 2012). Exposure of native freshwater mussels to fluoxetine induced premature release of glochidia resulting in non-viable larvae (Bringolf 2010), however most reports indicate increased serotinergic signaling results in the release of either viable gametes or glochidia.  Release is, in part, dependent on the water pumping rate and coordination with cilia, at least in some bivalves.   


Background (optional)

?



Summary of the AOP

?


Events: Molecular Initiating Events (MIE)

?

Key Events (KE)

?

Adverse Outcomes (AO)

?

Sequence Type Event ID Title Short name
1 MIE 619 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
2 KE 1142 Increased, valve movement Increased, valve movement
3 KE 621 Increase, cilia movement Increase, cilia movement
4 KE 1257 Induced parturition Induced parturition
5 KE 1256 increased mantel display increased mantel display
6 KE 626 Increased, serotonin (5-HT) Increased, serotonin (5-HT)
7 AO 1163 Increased, Reproductive Success Increased, Reproductive Success
8 AO 1164 Increased, Population Increased, Population

Relationships Between Two Key Events
(Including MIEs and AOs)

?

Title Adjacency Evidence Quantitative Understanding
increased mantel display leads to Induced parturition adjacent
Increased, Reproductive Success leads to Increased, Population adjacent
Induced parturition leads to Increased, Reproductive Success adjacent
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Increased, serotonin (5-HT) adjacent
Increased, serotonin (5-HT) leads to Increased, valve movement adjacent
Increased, valve movement leads to Induced parturition adjacent
Increase, cilia movement leads to Induced parturition adjacent
Increased, serotonin (5-HT) leads to increased mantel display adjacent
Increased, serotonin (5-HT) leads to Increase, cilia movement adjacent
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Increased, valve movement non-adjacent
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Increase, cilia movement non-adjacent
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to increased mantel display non-adjacent

Network View

?

 

Stressors

?

Life Stage Applicability

?

Taxonomic Applicability

?

Sex Applicability

?

Overall Assessment of the AOP

?



Domain of Applicability

?


Essentiality of the Key Events

?


Evidence Assessment

?


Quantitative Understanding

?


Considerations for Potential Applications of the AOP (optional)

?



References

?