API

Event: 1142

Key Event Title

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Increased, valve movement

Short name

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Increased, valve movement

Key Event Component

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Process Object Action
musculoskeletal movement valve increased

Key Event Overview

AOPs Including This Key Event

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AOP Name Role of event in AOP
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline KeyEvent
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline KeyEvent
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase KeyEvent
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase KeyEvent

Stressors

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Level of Biological Organization

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Biological Organization
Tissue


Organ term

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Taxonomic Applicability

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Term Scientific Term Evidence Link
bivalves Crassostrea corteziensis NCBI

Life Stages

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Sex Applicability

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How This Key Event Works

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In bivalves, the muscle involved in valve movement is the anterior byssus retractor muscle (ABRM). This muscle and other muscles can undergo a catch state of contraction, which is characterized by a very slowly decaying force in the absence of stimulation. When contraction of the ABRM (and other catch-capable muscles) is initiated by the neurotransmitter acetylcholine, it contracts actively and remains in the contracted state with minimal energetic investment (Güth et al. 1984; Butler et al. 1998) even after the acetylcholine stimulation has ceased and internal calcium stores are returned to basal levels(Ishii et al. 1989). This unique physiology allows the muscle to maintain a closed valve without depleting energy reserves. In mollusks, the catch state is terminated by serotonin.


How It Is Measured or Detected

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Evidence Supporting Taxonomic Applicability

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References

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