API XML

Aop: 98

AOP Title

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5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation

Short name:

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5-HTT block to incr. predation

Graphical Representation

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Click to download graphical representation template

Authors

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Bryan Brooks, Baylor University, USA

Kellie Fay, US EPA

Ksenia Groh, EAWAG, Switzerland

Point of Contact

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Ksenia Groh   (email point of contact)

Contributors

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  • Ksenia Groh

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) September 16, 2017 10:15
Increased, serotonin (5-HT) September 16, 2017 10:15
Decreased, anxiety December 03, 2016 16:37
Decreased, sheltering December 03, 2016 16:37
Increased, predation December 03, 2016 16:37
Increased, serotonin (5-HT) leads to Decreased, anxiety December 03, 2016 16:37
Decreased, anxiety leads to Decreased, sheltering December 03, 2016 16:37
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Increased, serotonin (5-HT) December 03, 2016 16:37
Decreased, sheltering leads to Increased, predation December 03, 2016 16:37

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 619 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
2 KE 626 Increased, serotonin (5-HT) Increased, serotonin (5-HT)
3 KE 627 Decreased, anxiety Decreased, anxiety
4 KE 629 Decreased, sheltering Decreased, sheltering
5 AO 588 Increased, predation Increased, predation

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Increased, serotonin (5-HT) adjacent
Increased, serotonin (5-HT) leads to Decreased, anxiety non-adjacent
Decreased, anxiety leads to Decreased, sheltering non-adjacent
Decreased, sheltering leads to Increased, predation non-adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Pimephales promelas Pimephales promelas NCBI
Echinogammarus marinus Gammarus marinus NCBI

Sex Applicability

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Overall Assessment of the AOP

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This putative AOP is based on a few studies in fish and mollusks and should be considered preliminary only.

Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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