API

Relationship: 1733

Title

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General Apoptosis leads to Neurodegeneration

Upstream event

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General Apoptosis

Downstream event

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Neurodegeneration

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
CYP2E1 activation and formation of protein adducts leading to neurodegeneration adjacent High High

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Neurodegeneration is the loss of neuron cells in the brain. Apoptosis is a form of cell death that can cause neurodegeneration. Neurodegeneration is linked with diseases such as Alzheimer.

Evidence Supporting this KER

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Apoptosis is a form of cell death, where neurodegeneration is the loss of neuron cells in the brain. 

Biological Plausibility

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Empirical Evidence

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Uncertainties and Inconsistencies

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More AOPs should be developed to link other forms of cell death with neurodegeneration.

Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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Uttara, B., Singh, A. V, Zamboni, P. & Mahajan, R. T. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr. Neuropharmacol. 7, 65–74 (2009).

Obulesu, M. & Lakshmi, M. J. Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues. Neurochemical Research 39, 2301–2312 (2014).