API

Event: 1028

Key Event Title

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Activation of specific nuclear receptors, PPAR-gamma activation

Short name

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Activation of specific nuclear receptors, PPAR-gamma activation

Biological Context

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Level of Biological Organization
Molecular

Cell term

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Cell term
hepatocyte


Organ term

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Key Event Components

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Process Object Action
peroxisome proliferator activated receptor signaling pathway peroxisome proliferator-activated receptor gamma decreased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
PPARgamma-related sarcomas MolecularInitiatingEvent
PPARG mod to adipogenesis KeyEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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How It Is Measured or Detected

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Domain of Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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Tetrabromobisphenol A

TBBPA binds to PPARγ in vitro, with a Kd of 0.78 µM and in vivo in zebrafish, with a LOEL of 100 nM  (Fang et al., 2015; Riu et al., 2011; Riu et al., 2014). Mild activation has also been reported in vitro in several research papers and in ToxCast assays as well, with effective doses ranging from 0.3 to 10 µM (Riu et al., 2011; Riu et al., 2014; Suzuki et al., 2013; ToxCastTM Data; Watt and Schlezinger, 2015).


References

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