API

Aop: 72

AOP Title

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Epigenetic modification of PPARG leading to adipogenesis

Short name:

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PPARG mod to adipogenesis

Authors

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Michelle Angrish, Brian Chorley, U.S. EPA

Point of Contact

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Michelle Angrish

Contributors

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  • Michelle Angrish

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite Under Development 1.29 Included in OECD Work Plan


This AOP was last modified on February 26, 2017 20:14

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Revision dates for related pages

Page Revision Date/Time
peroxisome proliferator activated receptor promoter demethylation September 16, 2017 10:14
Activation of specific nuclear receptors, PPAR-gamma activation September 16, 2017 10:17
obesity July 24, 2017 16:35
activation of CCAAT/enhancer-binding protein alpha July 24, 2017 16:37
increased adipogenesis July 24, 2017 16:38
decreased dopamine July 24, 2017 16:48
decreased reward July 24, 2017 16:45
decreased DNA methylation of tyrosine hydroxylase July 24, 2017 16:45
decreased methylation of dopamine transporter promoter July 24, 2017 16:46
chronic high fat diet July 24, 2017 16:46
demethylation, PPARg promoter leads to Activation of specific nuclear receptors, PPAR-gamma activation July 24, 2017 16:38
Activation of specific nuclear receptors, PPAR-gamma activation leads to increased adipogenesis July 24, 2017 16:39
activation of CEBPA leads to Activation of specific nuclear receptors, PPAR-gamma activation July 24, 2017 16:39
activation of CEBPA leads to increased adipogenesis July 24, 2017 16:40
increased adipogenesis leads to obesity July 24, 2017 16:40
chronic high fat diet leads to decreased dopamine July 24, 2017 16:47
decreased dopamine leads to decreased reward July 24, 2017 16:47
decreased reward leads to decreased DNA methylation of tyrosine hydroxylase July 24, 2017 16:47
decreased reward leads to decreased methylation of dopamine transporter promoter July 24, 2017 16:48
decreased reward leads to decreased dopamine July 24, 2017 16:48
decreased DNA methylation of tyrosine hydroxylase leads to obesity July 24, 2017 16:49
decreased methylation of dopamine transporter promoter leads to obesity July 24, 2017 16:49
decreased DNA methylation of tyrosine hydroxylase leads to decreased dopamine July 24, 2017 16:50
decreased methylation of dopamine transporter promoter leads to decreased dopamine July 24, 2017 16:50
Tributyltin July 24, 2017 16:32

Abstract

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Background (optional)

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Summary of the AOP

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Stressors

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Name Evidence Term
Tributyltin

Molecular Initiating Event

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Title Short name
peroxisome proliferator activated receptor promoter demethylation demethylation, PPARg promoter
chronic high fat diet chronic high fat diet

Key Events

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Title Short name
Activation of specific nuclear receptors, PPAR-gamma activation Activation of specific nuclear receptors, PPAR-gamma activation
activation of CCAAT/enhancer-binding protein alpha activation of CEBPA
increased adipogenesis increased adipogenesis
decreased dopamine decreased dopamine
decreased reward decreased reward
decreased DNA methylation of tyrosine hydroxylase decreased DNA methylation of tyrosine hydroxylase
decreased methylation of dopamine transporter promoter decreased methylation of dopamine transporter promoter

Adverse Outcome

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Title Short name
obesity obesity

Relationships Between Two Key Events (Including MIEs and AOs)

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Network View

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Graphical Representation

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Click to download graphical representation template

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Weight of Evidence Summary

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Quantitative Considerations

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Considerations for Potential Applications of the AOP (optional)

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References

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