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Aop: 72

AOP Title

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Epigenetic modification of PPARG leading to adipogenesis

Short name:

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PPARG mod to adipogenesis

Graphical Representation

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Click to download graphical representation template

Authors

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Michelle Angrish, Brian Chorley, U.S. EPA

Point of Contact

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Michelle Angrish   (email point of contact)

Contributors

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  • Michelle Angrish

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
peroxisome proliferator activated receptor promoter demethylation September 16, 2017 10:14
Activation of specific nuclear receptors, PPAR-gamma activation September 16, 2017 10:17
obesity July 24, 2017 16:35
activation of CCAAT/enhancer-binding protein alpha July 24, 2017 16:37
increased adipogenesis July 24, 2017 16:38
decreased dopamine July 24, 2017 16:48
decreased reward July 24, 2017 16:45
decreased DNA methylation of tyrosine hydroxylase July 24, 2017 16:45
decreased methylation of dopamine transporter promoter July 24, 2017 16:46
chronic high fat diet July 24, 2017 16:46
demethylation, PPARg promoter leads to Activation of specific nuclear receptors, PPAR-gamma activation July 24, 2017 16:38
Activation of specific nuclear receptors, PPAR-gamma activation leads to increased adipogenesis July 24, 2017 16:39
activation of CEBPA leads to Activation of specific nuclear receptors, PPAR-gamma activation July 24, 2017 16:39
activation of CEBPA leads to increased adipogenesis July 24, 2017 16:40
increased adipogenesis leads to obesity July 24, 2017 16:40
chronic high fat diet leads to decreased dopamine July 24, 2017 16:47
decreased dopamine leads to decreased reward July 24, 2017 16:47
decreased reward leads to decreased DNA methylation of tyrosine hydroxylase July 24, 2017 16:47
decreased reward leads to decreased methylation of dopamine transporter promoter July 24, 2017 16:48
decreased reward leads to decreased dopamine July 24, 2017 16:48
decreased DNA methylation of tyrosine hydroxylase leads to obesity July 24, 2017 16:49
decreased methylation of dopamine transporter promoter leads to obesity July 24, 2017 16:49
decreased DNA methylation of tyrosine hydroxylase leads to decreased dopamine July 24, 2017 16:50
decreased methylation of dopamine transporter promoter leads to decreased dopamine July 24, 2017 16:50
Tributyltin July 24, 2017 16:32

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 228 peroxisome proliferator activated receptor promoter demethylation demethylation, PPARg promoter
2 MIE 1454 chronic high fat diet chronic high fat diet
3 KE 1028 Activation of specific nuclear receptors, PPAR-gamma activation Activation of specific nuclear receptors, PPAR-gamma activation
4 KE 1448 activation of CCAAT/enhancer-binding protein alpha activation of CEBPA
5 KE 1449 increased adipogenesis increased adipogenesis
6 KE 1450 decreased dopamine decreased dopamine
7 KE 1451 decreased reward decreased reward
8 KE 1452 decreased DNA methylation of tyrosine hydroxylase decreased DNA methylation of tyrosine hydroxylase
9 KE 1453 decreased methylation of dopamine transporter promoter decreased methylation of dopamine transporter promoter
10 AO 1447 obesity obesity

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
demethylation, PPARg promoter leads to Activation of specific nuclear receptors, PPAR-gamma activation adjacent
Activation of specific nuclear receptors, PPAR-gamma activation leads to increased adipogenesis adjacent
activation of CEBPA leads to Activation of specific nuclear receptors, PPAR-gamma activation adjacent
activation of CEBPA leads to increased adipogenesis adjacent
chronic high fat diet leads to decreased dopamine adjacent
decreased dopamine leads to decreased reward adjacent
decreased reward leads to decreased DNA methylation of tyrosine hydroxylase adjacent
decreased reward leads to decreased methylation of dopamine transporter promoter adjacent
decreased reward leads to decreased dopamine adjacent
increased adipogenesis leads to obesity non-adjacent
decreased DNA methylation of tyrosine hydroxylase leads to obesity non-adjacent
decreased methylation of dopamine transporter promoter leads to obesity non-adjacent
decreased DNA methylation of tyrosine hydroxylase leads to decreased dopamine non-adjacent
decreased methylation of dopamine transporter promoter leads to decreased dopamine non-adjacent

Network View

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Stressors

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Name Evidence Term
Tributyltin

Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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