API

Event: 1670

Key Event Title

?

Lung cancer

Short name

?

Lung cancer

Biological Context

?

Level of Biological Organization
Organ


Organ term

?


Key Event Components

?

Process Object Action

Key Event Overview


AOPs Including This Key Event

?

AOP Name Role of event in AOP
Frustrated phagocytosis-induced lung cancer AdverseOutcome

Stressors

?


Taxonomic Applicability

?

Term Scientific Term Evidence Link
mammals mammals NCBI

Life Stages

?

Life stage Evidence
Adult

Sex Applicability

?

Term Evidence
Unspecific

Key Event Description

?


Lung cancer is one of the most prevalent cancer in the world. This cancer occur mainly at the level of bronchial cells and affect more rarely at the level of alveoli. Lung cancer affects more men rather than women because of tabacco consumption (trend is reversing). This disease is at the first place on terms of mortality due to the late detection (Cancer League, WHO).


How It Is Measured or Detected

?


Lung cancer can be measured in human by analysis of the sputum cytology, the chest X-ray and all the techniques usually used in this medical field.

In animal experiments, the OECD guidelines n°451 provide the procedure for the study of carcinogenesis development.


Domain of Applicability

?


Lung cancer can occur in mammals, male or female, generally in adults


Evidence for Perturbation by Stressor



Regulatory Significance of the Adverse Outcome

?



References

?