Aopwiki

Relationship: 299

Title
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Induction, Sustained Hepatotoxicity leads to Induction, Sustained Cell Proliferation

Upstream event
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Induction, Sustained Hepatotoxicity

Downstream event
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Induction, Sustained Cell Proliferation

Key Event Relationship Overview
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AOPs Referencing Relationship
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AOP Name	Adjacency	Weight of Evidence	Quantitative Understanding
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors	adjacent	High

Taxonomic Applicability
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Sex Applicability
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Life Stage Applicability
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Key Event Relationship Description
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Evidence Supporting this KER
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Biological Plausibility
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Empirical Evidence
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Uncertainties and Inconsistencies
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Quantitative Understanding of the Linkage
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Response-response Relationship
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Time-scale
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Known modulating factors
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Known Feedforward/Feedback loops influencing this KER
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Domain of Applicability
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