API

Relationship: 1281

Title

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TRPV1 activation, TRPV1 leads to Opening of calcium channel, Calcium influx

Upstream event

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TRPV1 activation, TRPV1

Downstream event

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Opening of calcium channel, Calcium influx

Key Event Relationship Overview

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AOPs Referencing Relationship

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Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Proton donors (e.g. capsacin) cause TRPV1 calcium channels to open, causing localized calcium transients and deplorarization of neuronal membrane which may lead to action potentials.

Evidence Supporting this KER

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Biological Plausibility

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The basic function of TRPV1 is known and is concordant with existing biological knowledge.

Empirical Evidence

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Extensive evidence from in vitro patch clamp and in vivo toxicity studies show that TRPV1 is molecularly sensitive to noxious heat, acids, and proton donors (Caterina et al, 1997, Gavva et al, 2004).

Uncertainties and Inconsistencies

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Molecular determinants of TRPV1 agonist activity are not yet fully characterized.

Quantitative Understanding of the Linkage

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EC50 values for receptor activation and action potential generation in neurons are known for many TRPV1 agonists. The sensitivity of the response to stimulus may be modified by other cell signals and conditions.

Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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