API

Event: 766

Key Event Title

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Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme

Short name

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Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme

Key Event Component

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Process Object Action
4-hydroxyphenylpyruvate dioxygenase activity 4-hydroxyphenylpyruvate dioxygenase (rat) decreased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
HPPD inhibition leading to corneal papillomas and carcinomas (in rat) MolecularInitiatingEvent

Stressors

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Level of Biological Organization

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Biological Organization
Molecular

Cell term

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Organ term

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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How This Key Event Works

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This key event commonly operates through HPPD inhibitors.


How It Is Measured or Detected

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Evidence Supporting Taxonomic Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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