Upstream eventNon-neuronal production of TNF, Epithelial irritation
Key Event Relationship Overview
AOPs Referencing Relationship
Life Stage Applicability
Key Event Relationship Description
TNF is a well-known mediator of pro-inflammatory signaling. Its local effects include leukocyte attraction, edema, and sensitivity to pain.
Evidence Supporting this KER
TNF signals through the TNF receptor family which is widespread in many tissues. TNF is a strong activator of NF-kB and MAPK pathways in cells.
Evidence for the role of TNF in inflammation is readily available in textbooks and resources on basic science.