API

Relationship: 1277

Title

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Non-neuronal production of TNF, Epithelial irritation leads to Leukocyte infiltration

Upstream event

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Non-neuronal production of TNF, Epithelial irritation

Downstream event

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Leukocyte infiltration

Key Event Relationship Overview

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AOPs Referencing Relationship

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Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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TNF is a well-known mediator of pro-inflammatory signaling. Its local effects include leukocyte attraction, edema, and sensitivity to pain.

Evidence Supporting this KER

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Biological Plausibility

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TNF signals through the TNF receptor family which is widespread in many tissues. TNF is a strong activator of NF-kB and MAPK pathways in cells.

Empirical Evidence

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Evidence for the role of TNF in inflammation is readily available in textbooks and resources on basic science.

Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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